Zoonotic Salmonella Infections: Transmission Dynamics and Control

Dear Colleagues,

Zoonotic Salmonella infections persist as a formidable One Health threat, fuelled by intensive food-animal production, globalized trade, and the rapid evolution of antimicrobial resistance (AMR). High-resolution genomic epidemiology now reveals complex transmission webs linking wildlife, livestock, food chains, and humans, with dominant serovars such as Typhimurium and invasive NTS lineages spreading across continents and supply networks. Concurrently, the mobilome—plasmids, phages, transposons, and integrative elements—reshapes the Salmonella resistome in real time, partitioning and disseminating MDR determinants that erode the utility of critically important drugs. Despite advances in whole-genome sequencing, phylodynamics, and source-attribution models, critical gaps remain, including in quantifying cross-species spill-over, deciphering drivers of mobilome plasticity, and translating genomic insights into scalable interventions along the food–water–environment interface. This Special Issue seeks cutting-edge original research and syntheses on transmission dynamics, resistance ecology, and innovative control strategies—spanning molecular, ecological, and policy dimensions—to accelerate evidence-based countermeasures against zoonotic Salmonella.

Dr. Chenghao Jia
Guest Editor

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