HIV/AIDS Epidemiology, Prevention and Diagnostics: Current State of Research

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Epidemiology of Infectious Diseases".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 1080

Special Issue Editors


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Guest Editor
College of Public Health Medical and Veterinary Sciences, James Cook University, Townsville, Australia
Interests: infectious diseases; health system strengthening; global health
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Public Health and Tropical Medicine, College of Public Health, Medical and Veterinary Sciences, James Cook University, Townsville, Australia
Interests: HIV; tuberculosis; epidemiology; global health

Special Issue Information

Dear Colleagues,

From the first clinical cases in men who have sex with men to developing clinical signs, the use of CD4-T-cells strata, self-administration of rapid diagnostic tests, the introduction of viral load measurements and resistance testing, and the development of safe and effective antiretroviral treatments, not many fields in medicine have seen as many advances as the field of HIV in the last 30 years.

Large public health interventions such as the prevention of mother-to-child transmission, the role of antiretroviral treatment,  male circumcision or treatment as prevention have shaped the epidemiology of HIV. Similarly, over the years, innovative ways of diagnosing HIV, especially in vulnerable groups, have evolved. and we can see the clear impact not only at the patient but also at the community level.  

We invite colleagues to contribute to this special article with original articles,  reviews or meta-analysis that provide new insight into current research in the global HIV epidemiology, prevention and diagnosis.

Dr. Lars Henning
Dr. Maria Castellanos
Guest Editors

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Keywords

  • HIV
  • AIDS
  • diagnostics
  • epidemiology
  • prevention

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Published Papers (1 paper)

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Research

13 pages, 244 KiB  
Article
Evaluation of HIV Late Presentation Trends: A Cross-Sectional Analysis from a Leading Ecuadorian Public Hospital
by Adriana D. Suarez-Vizcaino, Nicole C. Bustamante-Pancho, Juan S. Izquierdo-Condoy, Hugo Pereira-Olmos, I. Alberto Castillo and Esteban Ortiz-Prado
Pathogens 2025, 14(6), 598; https://doi.org/10.3390/pathogens14060598 - 18 Jun 2025
Viewed by 401
Abstract
The global impact of HIV is especially significant when diagnoses are made in advanced stages. While strategies exist to mitigate late presentations, Ecuador’s 2018–2022 strategic plan has not yet been evaluated. This study assesses the prevalence and implications of late and advanced HIV [...] Read more.
The global impact of HIV is especially significant when diagnoses are made in advanced stages. While strategies exist to mitigate late presentations, Ecuador’s 2018–2022 strategic plan has not yet been evaluated. This study assesses the prevalence and implications of late and advanced HIV presentations in Ecuador, using data from a reference hospital in Quito. A cross-sectional analysis of 436 medical records of people living with HIV from the “Hospital de Especialidades Eugenio Espejo” was conducted between November 2015 and February 2020. The data were divided into “Pre-Plan” and “Post-Plan” periods for comparative analysis. The mean CD4 T count showed a non-statistically significant increase in the post-plan period (January 2018–February 2020). Notably, 65.1% of patients presented late, and 39.4% had advanced disease. Demographic data indicated that 89.9% were men, and 54.1% were under 30 years of age. No characteristics were identified that were associated with advanced late presentation of HIV infection. Sexual orientation data revealed that 69.1% identified as homosexual or bisexual. A predominance of late and advanced presenters was identified in the post-plan period, associated with being employed (p < 0.05) and being drug users (p < 0.001). There was also a greater incidence of late presenters among immigrants in the post-plan period (p = 0.045). Despite the implementation of Ecuador’s 2018–2022 strategic plan for HIV, substantial challenges in reducing late presentations remain. This study suggests that early diagnoses have not significantly improved. Employed patients and drug users were more likely to present late, with drug users also accounting for many advanced cases. This study highlights the need for more focused and targeted strategies to supplement the existing plan. Full article
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