Tick-Borne Encephalitis Virus: 2nd Edition
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: closed (31 January 2026) | Viewed by 1026
Special Issue Editor
Interests: TBE; TBEV; tick; encephalitis; meningitis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Tick-borne encephalitis (TBE) is an emerging vector-borne disease in Europe caused by tick-borne encephalitis virus (TBEV), which belongs to the Flaviviridae family. The number of TBE cases in Europe varies depending on the country and ranges from a few cases up to 1000 cases per year. There are three distinct clinical forms of TBE: meningitis, meningoencephalitis, and meningoencephalomyelitis. In patients with meningoencephalitis and meningoencephalomyelitis, the course of the disease is more severe. The mortality rate is 1%–4%, and a fatal outcome is usually observed in elderly or immunodeficient patients, but occasionally in young persons also.
Although most patients quickly recover from the disease, some require further neurological and psychiatric treatment due to persisting symptoms. So‐called post‐encephalitic TBE syndrome was described in 35%–58% of patients. This may cause long‐term morbidity, which often affects the patient’s quality of life and forces a change in lifestyle. The most commonly reported symptoms are cognitive or neuropsychiatric complaints, balance disorders, headache, dysphasia, hearing defects, and limb paresis.
The pathogenesis of different clinical presentations and sequelae development in TBE has not been fully recognized, so far. TBE virus neurotropism preferentially targets large neurons of the anterior horns, medulla oblongata, pons, dentate nucleus, Purkinje cells, and striatum. It has been confirmed that the disease may lead to nerve cell destruction.
Although there is a vaccine available, treatment remains symptomatic.
This Special Issue will focus on, but not exclusively, the following areas of research:
- Epidemiological aspects of TBE;
- Pathogenesis and diagnostics of TBE in humans;
- Development of sequelae after TBE;
- Approach to prevention and treatment;
- Development of novel therapeutic strategies against TBE complications.
Prof. Dr. Anna Moniuszko-Malinowska
Guest Editor
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Keywords
- TBE
- TBEV
- tick
- encephalitis
- meningitis
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