Structure-Based Antiviral Drug Discovery

Dear Colleagues,

Despite remarkable progress in antiviral therapy, viral infections remain a major global health threat, affecting billions annually and triggering recurrent pandemics. The emergence of drug-resistant viral strains and the continuous discovery of novel viruses further exacerbate this challenge, creating an urgent need for innovative antiviral drugs.

Structure-based drug discovery (SBDD) has emerged as a pivotal strategy in antiviral development, leveraging high-resolution structural insights into viral targets (e.g., proteases, polymerases, and spike proteins) to design precise, mechanism-driven inhibitors. Amid persistent viral pandemics and the rise of drug-resistant strains, SBDD accelerates lead identification, optimizes binding affinity, and enhances therapeutic specificity—addressing unmet needs in antiviral therapy. This Special Issue aims to compile cutting-edge research on SBDD applications in antiviral drug discovery, covering structural biology advances, computational modeling, structure–activity relationship analyses, and preclinical validation. We invite submissions that advance our understanding of SBDD for diverse viruses and drive translational progress.

We look forward to featuring your impactful research, which will greatly benefit journal readers and the broader scientific community. Thank you.

Dr. Zhao Wang
Prof. Dr. Boshi Huang
Guest Editors

Manuscript Submission Information

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