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Special Issue "Folic Acid Fortification and Supplement Use: Unanticipated Benefits and Risks"
A special issue of Nutrients (ISSN 2072-6643).
Deadline for manuscript submissions: closed (30 November 2017).
Folate is an essential B vitamin for a broad range of biochemical reactions involving transfer of one-carbon groups, including purine and pyrimidine synthesis for RNA and DNA, amino acid interconversions, cell division, tissue growth and methylation. Deficiencies of folate or imbalance of its active and inactive forms and interactions with other B-vitamins, notably vitamin B12, may lead to perturbations that result in adverse health consequences. In addition, genetic polymorphisms and environmental factors can disturb the normal function of one-carbon metabolism with detrimental effects on human health. The successful introduction of widespread folic acid fortification of the diet to reduce the incidence of neural tube defects, as well as the widespread use of folic acid supplements has also been associated with several unanticipated consequences, some beneficial and some potentially detrimental. Although a vast volume of research has already been conducted in this area, there are still significant gaps in our knowledge that require further investigations. This Special Issue of Nutrients invites submission of manuscripts, original research or reviews of the scientific literature, focused on novel findings in relation to folic acid intake through fortification and supplement use that have had an effect on disease risk relating to the metabolic role of folate and its interaction with vitamin B12, as well as gene-nutrient interactions. These effects include fetal growth and programming; and risk of disease (e.g., birth defects and pregnancy related conditions, cancer, cardiovascular disease including hypertension, neuropsychiatric disease, allergic disorders and osteoporosis).
Prof. Dr. Ralph Green
Prof. Dr. Joshua W. Miller
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- folic acid
- Vitamin B12
- cardiovascular disease