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Nutrients
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The Role of Magnesium in Metabolic Diseases
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The Role of Magnesium in Metabolic Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".

Deadline for manuscript submissions: closed (25 October 2024) | Viewed by 2006

Special Issue Editors

Dr. Meng-Hua Tao

E-Mail Website
Guest Editor
Department of Public Health Sciences, Henry Ford Health System, Detroit, MI 48202, USA
Interests: magnesium; nutrition; epidemiology; metabolic diseases; health disparity; aging
Dr. Xiangzhu Zhu

E-Mail Website
Guest Editor
Department of Medicine, Division of Epidemiology, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN 37203, USA
Interests: magnesium; nutrition; biomarkers; fatty liver disease; digestive cancer; Alzheimer’s disease

Special Issue Information

Dear Colleagues,

Magnesium is an essential nutrient for human health. As the fourth most abundant cation in the human body and second most abundant intracellular cation, magnesium is involved in many essential physiological, biochemical, and cellular process. Magnesium has a major influence on the pathogenesis of metabolic diseases. Current evidence shows that a significant portion of the population do not meet the recommended magnesium intake levels.  There is strong evidence linking chronic low magnesium state with a number of chronic diseases, including diabetes and obesity. 

The aim of this Special Issue, “The Role of Magnesium in Metabolic Diseases”, is to provide cutting-edge research encompassing various aspects, including (but not limited to) the following:

  • Original epidemiological, clinical, and experimental studies examining the impacts of magnesium status on metabolic diseases;
  • Methodological papers focusing on the substantial obstacles faced when conducting thorough research where magnesium and metabolic diseases intersect;
  • Review articles (including systematic reviews and meta-analyses) on the relationship between magnesium intake and metabolic diseases in different populations.

Dr. Meng-Hua Tao
Dr. Xiangzhu Zhu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • magnesium
  • diabetes
  • metabolic syndrome
  • metabolic dysfunction-associated steatotic liver disease (MASLD)
  • hypertension
  • inflammatory bowel disease
  • obesity
  • osteoporosis

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Published Papers (1 paper)

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Research

15 pages, 246 KiB  
Article
Magnesium Depletion Score and Mortality in Individuals with Metabolic Dysfunction Associated Steatotic Liver Disease over a Median Follow-Up of 26 Years
by Lei Fan, Xiangzhu Zhu, Xinyuan Zhang, Shakirat Salvador, Xuehong Zhang, Martha J. Shrubsole, Manhal J. Izzy and Qi Dai
Nutrients 2025, 17(2), 244; https://doi.org/10.3390/nu17020244 - 10 Jan 2025
Viewed by 1594
Abstract
Metabolic dysfunction associated steatotic liver disease (MASLD) has been associated with increased risks of all-cause and cardiovascular disease (CVD) mortality. Identification of modifiable risk factors that may contribute to higher risks of mortality could facilitate targeted and intensive intervention strategies in this population. [...] Read more.
Metabolic dysfunction associated steatotic liver disease (MASLD) has been associated with increased risks of all-cause and cardiovascular disease (CVD) mortality. Identification of modifiable risk factors that may contribute to higher risks of mortality could facilitate targeted and intensive intervention strategies in this population. This study aims to examine whether the magnesium depletion score (MDS) is associated with all-cause and CVD mortality among individuals with MASLD or metabolic and alcohol associated liver disease (MetALD). Methods: A total of 3802 participants with MASLD or MetALD were followed up over a median of 26 years in the National Health and Nutrition Examination Survey (NHANES) III cohort. The MDS was calculated by aggregating four factors influencing the reabsorption capability of the kidneys. The associations between MDS and all-cause, CVD, and cancer mortality were quantified using Cox proportional hazard regression models. Results: In the combined MASLD + MetALD cohort, a higher MDS (>2) was associated with increased all-cause mortality (HR, 2.52; 95%CI, 1.77–3.61; p-trend < 0.0001) and CVD mortality (HR, 3.01; 1.87–4.86; p-trend < 0.0001) compared to MDS = 0; this association became stronger among participants who did not meet the estimated average requirement level of Mg intake (2.72; 1.69–4.37; p-trend = 0.0014) and those with a Fibrosis-4 index (FIB-4) < 1.3 (2.95; 1.69–5.15; p-trend = 0.0006). Conclusions: In individuals with MASLD or MetALD, higher MDS, indicative of worse global Mg status, was associated with an increased risk of all-cause and CVD mortality. Correcting global Mg deficiency in high-risk MASLD/MetALD patients may have long-term health benefits. Full article
(This article belongs to the Special Issue The Role of Magnesium in Metabolic Diseases)
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