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Maternal Nutrition, Metabolic Factors and Offspring Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition in Women".

Deadline for manuscript submissions: 20 October 2025 | Viewed by 894

Special Issue Editor


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Guest Editor
School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China
Interests: nutritional epidemiology; women’s health; maternal and infantile healthcare; phytochemicals and chronic diseases prevention; geriatric health; gut microbiota; food safety
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Special Issue Information

Dear Colleagues,

Growing evidence shows that maternal nutrition and metabolism from pre-conception to lactation exert long-lasting impacts on offspring health during the critical period of the first 1000 days of life. Mothers’ dietary intake shapes the production of metabolites that can cross the placenta and affect pregnancy outcomes and fetal development. Despite decreasing birth rates in developed countries, perinatal nutrition still receives great attention due to rising delivery age, increasing multiparity and potentially adverse outcomes related to assisted reproductive technology, as well as increasing prevalence of metabolic disorders worldwide. 

For this Special issue, we request the submission of both original studies and review articles that focus on the influence of maternal nutrition across pre-conception, gestation or lactation on various offspring health outcomes. We hope that this Special issue offer will up-to-date knowledge and valuable, novel insights for health professionals and scientific researchers. Papers combining a high academic standard with a practical focus are especially welcome, with topics of interest including but not limited to the following:

  1. Original papers should be human studies with an either observational or interventional study design. Studies exploring potential mechanisms in animals or cells are welcome but need to be integrated with findings from human studies. Findings based on large-scale open databases or biobanks are welcome, especially in combination with local dataset. Studies on mendelian randomization or nutrigenomics are also welcome.
  2. Nutritional factors include but are not limited to dietary protein, carbohydrates, fatty acids, vitamins, minerals, phytochemicals and dietary patterns, as well as quality and quantity assessments. Dietary factors, in combination with environmental contaminants, are welcome, with particular interest in the assessment of the balance of health benefits and harmful effects. Submissions related to the evaluation of maternal nutrition using innovative strategies, such as epigenomics, gut microbiota, metabolomics, and lipidomics, are also of interest.
  3. Maternal metabolic conditions include but are not limited to gestational diabetes, hypertension, hyperlipidemia, obesity, gestational metabolic syndromes, fatty liver diseases, and thyroid dysfunction, as well as their respective risk factors.
  4. The health of offspring is a comprehensive topic, though we have a particular interest in fetal growth and development, adverse birth outcomes, infantile/childhood immune function, allergic diseases/infections, metabolic and cardiovascular diseases, and endocrinal or neurodevelopment disorders.

Dr. Zhaomin Liu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • perinatal nutrition
  • dietary factors
  • metabolic factors or conditions
  • endocrinal health
  • gestational complications
  • birth outcomes
  • childhood immune function
  • allergic disorders
  • infectious diseases
  • cardiometabolic risk
  • neurodevelopment disorders

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Published Papers (1 paper)

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Research

21 pages, 930 KiB  
Article
Extra-Thyroidal Impacts of Serum Iodine Concentrations During Early Pregnancy on Metabolic Profiles and Pregnancy Outcomes: Prospective Study Based on Huizhou Mother–Infant Cohort
by Zhaomin Liu, Chaogang Chen, Cheng Wang, Yaqian Wang, Minmin Li and Wenjing Pan
Nutrients 2025, 17(10), 1626; https://doi.org/10.3390/nu17101626 - 9 May 2025
Viewed by 579
Abstract
Objectives: This study aimed to test the extra-thyroidal impacts of maternal serum iodine concentrations (SICs) on metabolic factors and subsequent pregnancy outcomes. Methods: Single pregnant women aged 18–49 years were recruited during their first prenatal visits. SICs at first trimester (T1) were tested [...] Read more.
Objectives: This study aimed to test the extra-thyroidal impacts of maternal serum iodine concentrations (SICs) on metabolic factors and subsequent pregnancy outcomes. Methods: Single pregnant women aged 18–49 years were recruited during their first prenatal visits. SICs at first trimester (T1) were tested by ICP-MS. Metabolic factors [body mass index (BMI), fat %, glucose, lipids, uric acid, and blood pressure] were measured, and composite indices [the triglyceride–glucose (TyG) index, TyG-BMI, and the Framingham steatosis index (FSI)] were estimated. Obstetric and birth outcomes were retrieved from the hospital information system, including gestational diabetes (GDM), gestational hypertension (GH), fetal distress, postpartum hemorrhage, premature rupture of membrane, small and large for gestational age (SGA and LGA), preterm birth, and low birth weight. Multivariable linear and logistic regression models were applied to explore the associations between maternal SIC, metabolic factors, and pregnancy outcomes. Results: A total of 1456 mothers were included for analysis. Maternal LgSIC values at T1 were inversely associated with early gestational weight gain (β = −0.113, p < 0.001) and BMI at T1 (β = −0.070, p = 0.006), but they were positively associated with triglycerides (β = 0.142, p < 0.001), the TyG index (β = 0.137, p < 0.001), and uric acid (β = 0.060, p = 0.018). However, upon further adjustment for thyroid hormones, the associations were attenuated. The joint effects of high SIC and metabolic conditions (hyperlipidemia, high FSI, and GH) suggested increased adverse pregnancy outcomes (increased postpartum bleeding, reduced birth length, and reduced delivery weeks). Conclusions: Our prospective data in the iodine replete region indicated that high SICs at T1 were associated with increased risk of metabolic conditions and adverse birth outcomes, with the associations being independent of thyroid hormones. Full article
(This article belongs to the Special Issue Maternal Nutrition, Metabolic Factors and Offspring Health)
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