Human Diversity in Nutrient Metabolism: From Mechanisms to Precision Dietary Guidance
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrigenetics and Nutrigenomics".
Deadline for manuscript submissions: 10 December 2026 | Viewed by 41
Special Issue Editor
Interests: nutrigenetic; nutrigenomics; clinical nutrition; obesity; digestion
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Human diversity—encompassing genetic and environmental variations—explains why individuals have distinct metabolic responses, differing nutritional requirements, and varying susceptibilities to diseases. Nutrigenetics explores how genetic variations affect individual responses to nutrients and dietary patterns, significantly impacting metabolic regulation, disease susceptibility, and treatment outcomes. Interactions between genes and the environment contribute to varied responses in complex common morbidities such as obesity and metabolic syndrome. Recent advancements in genomics, multi-omics integration, and machine learning have accelerated the identification of genetic variants linked to dietary impacts and metabolic pathways, facilitating better modeling of genotype–phenotype relationships. This progress paves the way for personalized nutrition strategies, predictive risk assessments, and targeted dietary interventions.
This Special Issue aims to enhance our understanding of how genetic variation influences nutrient metabolism and dietary needs across diverse populations. By merging fundamental biology with human variability and clinical relevance, it seeks to establish a robust basis for evidence-based precision nutrition, connecting molecular discoveries with practical applications in public health.
I am pleased to invite you to contribute original research, human studies, experimental trials, cohort analyses, systematic reviews, and innovative methodological contributions. Particularly welcome are issues regarding insights into functional genetic variants, gene–nutrient interactions, metabolic regulation, and multi-omics approaches. A focus on capturing human diversity—including genetic ancestry, sex differences, cultural dietary exposures, and health disparities—is of importence. Rigorous studies linking genotype to phenotype through validated biomarkers, controlled interventions, and deep phenotyping are encouraged, alongside methodological papers addressing reproducibility and predictive analytics.
Prof. Dr. Ruth Birk
Guest Editor
Manuscript Submission Information
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Keywords
- nutrigenetics
- nutrigenomics
- epigenomics
- transcriptomics
- proteomics
- metabolomics
- gene–nutrient interactions
- inter-individual variability in nutrition
- polygenic score
- pathway modeling, predictive analytics
- validated metabolic and nutritional biomarkers
- controlled dietary interventions
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