nutrients-logo

Journal Browser

Journal Browser

Diet and Feeding for Children with Cancer

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Pediatric Nutrition".

Deadline for manuscript submissions: closed (25 September 2025) | Viewed by 155

Special Issue Editor


E-Mail Website
Guest Editor
Pediatric Oncology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy
Interests: pediatrics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In 2013, the Academy of Nutrition and Dietetics of the American Society of Parenteral and Enteral Nutrition (ASPEN) defined pediatric malnutrition status as “an imbalance between nutritional needs and nutrient intake, resulting in a cumulative deficit of energy, protein, or micronutrients that may adversely affect growth, development, and other clinical outcomes”. In children affected by cancer, the presence of a growing neoplastic mass leads to an increased need for nutrients. However, at the same time, chemotherapy and radiotherapy lead to mucositis and inflammation in the gastrointestinal system, which cause a reduction in the ability to feed adequately. This discordance between the body’s need for nutrients and the ability to feed leads to malnutrition and subsequent sarcopenia. Recent studies have shown that malnutrition and sarcopenia influence the prognosis of children with cancer. Moreover, in children who have recovered from cancer, malnutrition and sarcopenia can cause an increase in cardiovascular risk. Adequate diet and feeding represent important tools in the treatment of childhood cancer patients, and our knowledge in this field must be strengthened in order to achieve recovery and good prognoses.

Dr. Alberto Romano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • childhood cancer
  • childhood malnutrition
  • cancer survivor
  • sarcopenia
  • chemotherapy late effects
  • radiotherapy late effects

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Other

25 pages, 560 KB  
Systematic Review
Nutritional and Supplemental Interventions for Prevention and Treatment of Oral Mucositis in Pediatric Oncology
by Razvan Mihai Horhat, Alexandru Alexandru, Cristiana-Smaranda Ivan, Norberth-Istvan Varga, Madalina-Ianca Suba, Elena Ciurariu, Monica Susan, Razvan Susan and Adrian Cote
Nutrients 2025, 17(22), 3521; https://doi.org/10.3390/nu17223521 - 11 Nov 2025
Abstract
Background: Oral mucositis (OM) is a frequent complication of anticancer therapy which arises from cytotoxic injury, having significant clinical implications. Nutritional and supplement-based interventions have been proposed as adjunctive strategies to improve outcomes. Objectives: This systematic review aimed to identify and [...] Read more.
Background: Oral mucositis (OM) is a frequent complication of anticancer therapy which arises from cytotoxic injury, having significant clinical implications. Nutritional and supplement-based interventions have been proposed as adjunctive strategies to improve outcomes. Objectives: This systematic review aimed to identify and synthesize evidence from randomized controlled trials (RCTs) evaluating nutritional or natural supplement interventions for prevention or management of OM in pediatric oncology. Methods: We conducted a systematic search (17 August 2025) of Scopus, PubMed/MEDLINE, and Google Scholar (1 January 2000–1 June 2025) following PRISMA guidelines and registered in PROSPERO (CRD420251134454). The review included randomized controlled trials in pediatric cancer patients (≤18 years; up to 25 years for follow-up) receiving chemo-/radiotherapy, assessing nutritional, dietary, or natural product interventions for oral mucositis prevention or treatment. Non-randomized, adult, non-English, non-peer-reviewed, or inaccessible studies were excluded. Outcomes included incidence, severity, duration of OM, and mucositis-associated pain. Risk of bias was assessed using the NIH Study Quality Assessment Tools and the Cochrane RoB 2 tool. Results were qualitatively summarized. Results: Of 5870 records identified, 20 RCTs met inclusion criteria resulting in 1430 total included patients. Interventions tested included systemic supplements (e.g., glutamine, zinc, and bovine colostrum), topically applied agents (e.g., honey, vitamin E, Aloe vera, and olive oil), and nutrient-containing rinses (e.g., chamomile, Caphosol, and Traumeel S). Honey-based interventions showed promising outcomes. Discussion: Study designs and sample sizes varied considerably, and outcome measures were heterogeneous. Challenges with blinding, variable compliance, and inconsistent reporting reduce confidence and precision in the findings. Conclusions: Evidence from pediatric RCTs remains limited but highlights nutritional and natural products as promising supportive care options for OM. Findings suggest potential for practical, low-cost adjuncts to established oral care protocols, warranting further high-quality multicenter trials. Full article
(This article belongs to the Special Issue Diet and Feeding for Children with Cancer)
Show Figures

Figure 1

Back to TopTop