Biological and Clinical Implication of Fatty Acids in Liver and Cardiometabolic Disorders

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Lipids".

Deadline for manuscript submissions: 5 June 2024 | Viewed by 5117

Special Issue Editor


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Guest Editor
Lipoprotein Metabolism Section, Translational Vascular Medicine Branch, National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892-1666, USA
Interests: atherosclerosis; lipoproteins; inflammation; cardiology; bioactive lipids; imaging; cardiovascular disease; prevention

Special Issue Information

Dear Colleagues,

Cardiometabolic disorders represent a significant public health concern, which puts millions of people worldwide at a higher risk of developing heart disease and type 2 diabetes with associated healthcare expenses. Among the established risk factors comprising cardiometabolic disorders, such as abdominal obesity, insulin resistance and hypertension, non-alcoholic fatty liver disease (NAFLD) has been of particular clinical interest. Moreover, accompanying dyslipidemia, elevated triglycerides and impaired resolution of inflammation compelled international experts to revise the current understanding of NAFLD and propose a new definition, that more accurately represents pathophysiological mechanisms behind NAFLD and cardiometabolic complications. Thus, metabolic dysfunction-associated fatty liver disease (MAFLD) term has been coined. Finally, with the recent progress in fatty acids research and clinical application of n–3 fatty acids, particularly icosapent ethyl (IPE) treatment, this Special Issue of Nutrients should be of great interest to the wide community of researchers and healthcare professionals from different fields of study.

Dr. Alexander V. Sorokin
Guest Editor

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Keywords

  • fatty acids
  • inflammation
  • lipid mediators
  • lipoproteins
  • cardiometabolic disorders
  • liver disease
  • atherosclerosis
  • dyslipidemia
  • diet

Published Papers (1 paper)

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Review

17 pages, 666 KiB  
Review
Different Dietary Approaches, Non-Alcoholic Fatty Liver Disease and Cardiovascular Disease: A Literature Review
by Jose D. Torres-Peña, Antonio P. Arenas-de Larriva, Juan F. Alcala-Diaz, Jose Lopez-Miranda and Javier Delgado-Lista
Nutrients 2023, 15(6), 1483; https://doi.org/10.3390/nu15061483 - 20 Mar 2023
Cited by 3 | Viewed by 4635
Abstract
Non-alcoholic fatty liver disease (NAFLD) is the first cause of chronic liver disease and is also associated with other harmful entities such as obesity, metabolic syndrome, dyslipidemia, and diabetes. NAFLD is a significant public health concern worldwide, impacting individuals of all ages, and [...] Read more.
Non-alcoholic fatty liver disease (NAFLD) is the first cause of chronic liver disease and is also associated with other harmful entities such as obesity, metabolic syndrome, dyslipidemia, and diabetes. NAFLD is a significant public health concern worldwide, impacting individuals of all ages, and its prevalence is projected to increase in the near future due to its connection with obesity. Intrinsic (genetics) and external (lifestyle) factors may also modulate NAFLD, and, in turn, may partly explain the observed relationship between NAFLD and cardiovascular disease (CVD). Although many drugs are been tested to treat NAFLD, to date, no drug has indication to specifically treat this disorder. Thus, the current management of NAFLD relies on lifestyle modifications and specifically on weight loss, physical activity, and the intake of a healthy diet. In the present narrative review, we will discuss the effects of certain dietary patterns on NAFLD incidence and progression. Full article
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