Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
9.1
5.0
Journals
Nutrients
Special Issues
Assessment of Vitamin Deficiency and Benefits of Vitamin Supplementation for...
nutrients-logo
Submit to Special Issue Submit Abstract to Special Issue Review for Nutrients Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Assessment of Vitamin Deficiency and Benefits of Vitamin Supplementation for Human Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition Methodology & Assessment".

Deadline for manuscript submissions: 5 November 2025 | Viewed by 6223

Special Issue Editor

Prof. Dr. Manfred Eggersdorfer

E-Mail Website
Guest Editor
Department of Internal Medicine, University Medical Center Groningen, 9713 GZ Groningen, The Netherlands
Interests: vitamins; nutrients; optimal nutritional status
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Vitamins are essential nutrients that the body needs to function properly. One’s intake via their diet is often inadequate compared to recommendations. Recommendations are often defined to avoid deficiencies. However, it is no longer about vitamin deficiency. Optimal status provides many health benefits. In the Special Issue, the following aspects should be covered:

- What are cut off points for deficiency, suboptimal status, and optimal status?
- Which biomarkers should be used to assess vitamin status?
- What are the benefits of optimal status for long-term health?

Also, the contributions should next address the benefits of single vitamins and how vitamins work in concert regarding the optimal range.

Prof. Dr. Manfred Eggersdorfer
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vitamins
  • intake
  • optimal status
  • health benefits
  • deficiency

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

13 pages, 5754 KB  
Article
Increasing Prevalence of Potential Vitamin D Toxicity and Its Risk Factors in Korea: A Large Population-Based Study
by Rihwa Choi, Gayoung Chun, Sung-Eun Cho, Sunhyun Ahn, Sang Gon Lee and Eun Hee Lee
Nutrients 2025, 17(16), 2614; https://doi.org/10.3390/nu17162614 - 12 Aug 2025
Viewed by 2792
Abstract
Background/Objectives: Vitamin D plays an important role in a wide range of health outcomes, including immune regulation, bone metabolism, cardiovascular health, and cancer prevention. However, recent data on the prevalence and risk factors for elevated serum 25-hydroxyvitamin D [25(OH)D] concentrations—indicative of potential [...] Read more.
Background/Objectives: Vitamin D plays an important role in a wide range of health outcomes, including immune regulation, bone metabolism, cardiovascular health, and cancer prevention. However, recent data on the prevalence and risk factors for elevated serum 25-hydroxyvitamin D [25(OH)D] concentrations—indicative of potential vitamin D toxicity—remain limited in Korea. Methods: We conducted a retrospective analysis of laboratory data from individuals who underwent serum 25(OH)D testing between 2020 and 2022. Potential vitamin D toxicity was defined as serum 25(OH)D levels exceeding 50, 100, or 150 ng/mL. The prevalence of potential toxicity was examined by age, sex, test month, and year. Results: A total of 1,198,947 individuals (mean age, 45.7 ± 19.4 years; 31.6% male) were included in the study. The prevalence of serum 25(OH)D > 50 ng/mL increased from 4.41% in 2020 to 6.21% in 2022, and that of >100 ng/mL rose from 0.09 to 0.12% over the same period. The proportions exceeding 50 and 100 ng/mL also rose significantly (p < 0.05), while >150 ng/mL remained rare (0.01%) and stable. Elevated 25(OH)D concentrations were more frequently observed among females, children aged 0–9 years, and adults aged ≥50 years (adjusted odds ratios for multivariable logistic regression > 1.0, p < 0.05). Conclusions: Although the prevalence of potential vitamin D toxicity remains low, its continuous upward trend highlights the need for increased public awareness, clinical monitoring, and guideline-based supplementation strategies to prevent inadvertent vitamin D intoxication, particularly in the aging population. Full article
(This article belongs to the Special Issue Assessment of Vitamin Deficiency and Benefits of Vitamin Supplementation for Human Health)
►▼ Show Figures

Figure 1

19 pages, 1157 KB  
Article
Examination of Genetic and Epigenetic Characteristics of Patients with Hyperhomocysteinemia Following High-Dose Folic Acid Consumption
by Barbara K. Bartak, Zsofia B. Nagy, Nikolett Szakallas, Alexandra Kalmar, Eszter Farkas, Fruzsina Banyai, Orsolya Pipek, Istvan Csabai, Nora Sydo, Emese Csulak, Bela Merkely, Istvan Takacs and Bela Molnar
Nutrients 2025, 17(13), 2133; https://doi.org/10.3390/nu17132133 - 27 Jun 2025
Viewed by 1128
Abstract
Purpose: Homocysteine (HCY) metabolism is regulated by the methionine cycle, which is essential for DNA methylation and is associated with the folate cycle. This study examines the alterations in DNA methylation signature including epigenetic age changes, measure cell-free DNA (cfDNA), and HCY concentrations, [...] Read more.
Purpose: Homocysteine (HCY) metabolism is regulated by the methionine cycle, which is essential for DNA methylation and is associated with the folate cycle. This study examines the alterations in DNA methylation signature including epigenetic age changes, measure cell-free DNA (cfDNA), and HCY concentrations, and identifies genetic markers that may influence homocysteine response following folic acid (FA) supplementation in individuals with hyperhomocysteinemia (HHC). Methods: Blood samples were obtained from 43 HHC patients undergoing FA supplementation. We quantified FA and HCY levels, separated plasma and white blood cell fractions, and evaluated global DNA methylation using LINE-1 bisulfite pyrosequencing. Biological age was determined using Illumina BeadArray technology, and whole-exome sequencing was performed to investigate the patients’ genetic backgrounds. Results: Following FA supplementation, cfDNA levels significantly decreased and correlated positively with HCY (r = 0.2375). Elevated average LINE-1 methylation of cfDNA and PBMC-origin DNA was observed, with mean relative changes of 1.9% for both sample types. Regarding HCY levels, we categorized patients based on their response to FA supplementation. FA responders showed decreased HCY from 15.7 ± 5.5 to 11 ± 2.9 µmol/L, while in FA non-responders, an opposite trend was detected. The average biological age was reduced by 2.6 years, with a notable reduction observed in 80% of non-responders and 48% of responders. Sequencing identified mutations in several genes related to the one-carbon cycle, including MTRR, CHAT, and MTHFD1, with strong correlations to the non-responder phenotypes found in genes like PRMT3, TYMS, DNMT3A, and HIF3A. Conclusions: FA supplementation influences the HCY level, as well as affects the cfDNA amount and the DNA methylation pattern. However, genetic factors may play a crucial role in mediating individual responses to folate intake, emphasizing the need for personalized approaches in managing hyperhomocysteinemia. Full article
(This article belongs to the Special Issue Assessment of Vitamin Deficiency and Benefits of Vitamin Supplementation for Human Health)
►▼ Show Figures

Figure 1

16 pages, 1563 KB  
Article
Low Vitamin D Status Attenuates Hypolipidemic and Pleiotropic Effects of Atorvastatin in Women
by Robert Krysiak, Karolina Kowalcze, Witold Szkróbka and Bogusław Okopień
Nutrients 2025, 17(10), 1674; https://doi.org/10.3390/nu17101674 - 15 May 2025
Viewed by 1269
Abstract
Background/Objectives: Low vitamin D status seems to be associated with increased cardiometabolic risk, and was found to attenuate cardiometabolic benefits of statins in men. The aim of the current study was to investigate whether a different vitamin D status determines the pleiotropic [...] Read more.
Background/Objectives: Low vitamin D status seems to be associated with increased cardiometabolic risk, and was found to attenuate cardiometabolic benefits of statins in men. The aim of the current study was to investigate whether a different vitamin D status determines the pleiotropic effects of statins in women. Methods: This pilot, single-center, prospective, matched-cohort study included 78 women with hypercholesterolemia requiring statin therapy, assigned into one of three age-, plasma lipid-, and body mass index-matched groups: women with vitamin D deficiency (group I), women with vitamin D insufficiency (group II), and women with normal vitamin D homeostasis (group III). Throughout the study (16 weeks), all patients were treated with atorvastatin. The outcome of interest included plasma lipids, glucose homeostasis markers (fasting glucose, HOMA-IR and glycated hemoglobin), plasma levels of 25-hydroxyvitamin D, creatine kinase, uric acid, high-sensitivity C-reactive protein, homocysteine, fibrinogen, urinary albumin-to-creatinine ratio (UACR), and computed values of a 10-year risk of atherosclerotic events. Results: Compared to the control group (group III), group I was characterized by higher values of HOMA-IR, glycated hemoglobin, uric acid, hsCRP, homocysteine, fibrinogen, a UACR, and a 10-year risk of atherosclerotic events, whereas group II had higher values of hsCRP, homocysteine and a UACR. Atorvastatin reduced plasma levels of total and LDL cholesterol and a 10-year risk of atherosclerotic events in all study groups, but this effect was weakest in group I and strongest in group III. In group III, the drug decreased uric acid, hsCRP, homocysteine, fibrinogen, and the UACR. In the remaining groups, its effect was limited to a small decrease in only hsCRP (group I) or in hsCRP and homocysteine (group II). In group I, atorvastatin treatment was associated with an increase in HOMA-IR, glycated hemoglobin, and creatine kinase. Conclusions: Low vitamin D status may exert an unfavorable effect on the lipid-dependent and lipid-independent effects of atorvastatin in middle-aged or elderly women. Full article
(This article belongs to the Special Issue Assessment of Vitamin Deficiency and Benefits of Vitamin Supplementation for Human Health)
►▼ Show Figures

Figure 1

Review

Jump to: Research

21 pages, 2064 KB  
Review
CYP24A1 in Small Intestinal Vitamin D Metabolism and Clinical Implications
by Agnieszka Nowacka, Maciej Śniegocki, Dominika Bożiłow and Ewa A. Ziółkowska
Nutrients 2025, 17(21), 3348; https://doi.org/10.3390/nu17213348 - 24 Oct 2025
Viewed by 410
Abstract
CYP24A1, a mitochondrial cytochrome P450 enzyme, plays a critical role in the catabolism of active vitamin D metabolites and is a key regulator of local vitamin D signaling in the small intestine. While traditionally studied in the context of renal physiology, increasing evidence [...] Read more.
CYP24A1, a mitochondrial cytochrome P450 enzyme, plays a critical role in the catabolism of active vitamin D metabolites and is a key regulator of local vitamin D signaling in the small intestine. While traditionally studied in the context of renal physiology, increasing evidence highlights its distinct regulatory mechanisms and functional significance within the intestinal epithelium. This review explores the molecular architecture, tissue-specific expression patterns, and multifactorial regulation of CYP24A1 in enterocytes, encompassing nuclear receptor signaling, epigenetic and post-transcriptional control, and environmental influences such as inflammation, diet, and the gut microbiota. We discuss how intestinal CYP24A1 modulates the expression of vitamin D target genes involved in transcellular calcium absorption and epithelial barrier function, and how its dysregulation contributes to gastrointestinal disorders including inflammatory bowel diseases, celiac disease, microbiota dysbiosis, and colorectal cancer. In addition, we examine preclinical and translational evidence supporting CYP24A1 as a potential therapeutic target. Emerging strategies such as selective enzyme inhibitors, microbiota modulation, RNA-based technologies, and personalized supplementation approaches are considered in the context of restoring local vitamin D bioactivity and mineral homeostasis. Together, this review underscores the clinical importance of intestinal CYP24A1 and highlights novel opportunities for targeted interventions in vitamin D-responsive gastrointestinal pathologies. Full article
(This article belongs to the Special Issue Assessment of Vitamin Deficiency and Benefits of Vitamin Supplementation for Human Health)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop