Special Issue "Impact of Food Additives and Supplements on Gastrointestinal and Systemic Health"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 31 October 2020.

Special Issue Editors

Prof. Dr. Federica I. Wolf
Website1 Website2
Guest Editor
Università Cattolica del Sacro Cuore, Faculty of Medicine and Fondazione Policlinico Gemelli IRCCS, Rome, Italy
Interests: magnesium homeostasis; magnesium transport; magnesium channels; oxidative stress; cancer cells; cellular aging; signal transduction;IBD and gut microbiota, food supplements and health
Special Issues and Collections in MDPI journals
Dr. Valentina Petito
Guest Editor
Univ Cattolica Sacro Cuore, Ist Patol Speciale Med, Largo F Vito 8, I-00168 Rome, Italy
Interests: Gut Microbiota; probiotics; mucosal immunology; Inflammatory Bowel Disease; microbiome sequencing; bioinformatics; Translational research
Dr. Valentina Trapani
Guest Editor
Patologia Generale, Facoltà di MEDICINA E CHIRURGIA, Università Cattolica del Sacro Cuore, Rome, Italy
Interests: magnesium absorption; magnesium channels; cell proliferation; human diseases, preventive medicine, aging
Special Issues and Collections in MDPI journals
Dr. Franco Scaldaferri
Guest Editor
Dip. Sci. Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche Fondazione Policlinico Universitario "A. Gemelli" IRCCS, 00168, Rome, Italy
Interests: Inflammatory Bowel Disease; Digestive Disease; Colon cancer; Gut Microbiota; Intestinal Permeability; Probiotics; Prebiotics; Fecal Microbiota Transplantaion

Special Issue Information

Dear Colleagues,

In the last fifty years, industrialization and westernization of lifestyle have brought about an exponential increase in the incidence of many diseases, most notably cardiovascular, metabolic, and gastrointestinal disorders. Many recent studies have shown an association between gut microbiota dysbiosis and these noncommunicable diseases, and wide research efforts are currently dedicated to understanding the factors that contribute to maintaining a healthy microbiota and having a positive impact on global health.

Diet is one of the key modulators of gut microbiota composition. Noteworthy,  Western diet is characterized by low intake of fruit, legumes, and vegetable fibers and high intake of red meat, dairy, eggs and refined grains, saturated fat, sugar, and salt may promote dysbiosis. In addition, there is increasing awareness that also food additives, which are commonly present in Western processed foods (dyes, colour stabilizers, flavorings, flavor enhancers, nonsugar sweeteners, processing aids such as carbonating, firming, bulking and anti-bulking, de-foaming, anticaking and glazing agents, emulsifiers), can exert deleterious effects in the gut. A deeper understanding of the impact of those food additives on gut homeostasis is much needed, in view of their possible involvement in the development of gastrointestinal and other non-communicable diseases.

To counterweigh the pitfalls of the Western diet, food supplements, including minerals, vitamins, and antioxidants, are widely used, despite poor characterization of their interaction with microbiota, as well as food components and food additives. With the ultimate aim of developing safe and cost-effective nutritional interventions as preventive or adjuvant strategies for many conditions, it is imperative to assess the potential to modulate a healthy gut microbiota through diverse food supplements, additives, and pre- or pro-biotics.

Here, we invite experts to contribute to this Special Issue with original research or review articles that investigate the relationships between food additives/supplements and the gut microbiota, as well as their role in human health, which may suggest novel preventive and/or therapeutic nutritional approaches.

Prof. Dr. Federica I. Wolf
Dr. Valentina Petito
Dr. Valentina Trapani
Dr. Franco Scaldaferri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Food additives
  • Food supplements
  • Gut–brain axis
  • Gut microbiota
  • IBD
  • IBS
  • Noncommunicable diseases
  • Personalized medicine
  • Uptake mechanisms

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:


Open AccessArticle
Development and Validation of Surveys to Estimate Food Additive Intake
Nutrients 2020, 12(3), 812; https://doi.org/10.3390/nu12030812 - 19 Mar 2020
(1) Background: The Food Agricultural Organization/World Health Organization (FAO/WHO) International Food Standards Codex Alimentarius CXS 192e International Food Standards (hereafter, CODEX) declares additives non-toxic, but they have been associated with changes to the microbiota changes and thinning of the mucus layer of the [...] Read more.
(1) Background: The Food Agricultural Organization/World Health Organization (FAO/WHO) International Food Standards Codex Alimentarius CXS 192e International Food Standards (hereafter, CODEX) declares additives non-toxic, but they have been associated with changes to the microbiota changes and thinning of the mucus layer of the gut. Their widespread use has occurred in parallel with increased inflammatory bowel disease (IBD) incidence. This paper reports on the development and validation of surveys to estimate additive intake. (2) Methods: Dietitians created a food-additive database, with a focus on additives that have been associated with IBD. For each additive, information on the CODEX food-category they are permitted in and the associated maximum permissible levels (mg/kg) was recorded. Based on the database, questions to assess early life (part 1) and recent (part 2) additive intake were written. Forward–backward translation from English to Chinese was undertaken. Thirty-one individuals were evaluated to assess understandability. A further fifty-seven individuals completed the tool on two occasions, a fortnight apart; agreement was assessed using Cohen’s kappa coefficient or the intra-class correlation coefficient (ICC). (3) Results: The participants reported that it was difficult to remember food intake and estimate portion sizes. The participants also noted confusion around the term ‘home-grown’. Instructions and definitions were added; after this, respondents judged the questionnaires as clear. The average kappa coefficient for part 1 and part 2 questions were 0.61 and 0.67, respectively. The average ICC ranged from 0.30 to 0.94; three food lists were removed due to low reliability. (4) Conclusions: Two tools have been created and validated, in two languages, that reliably assess remote and recent food additive intake. Full article
Back to TopTop