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Dietary Management of Gastrointestinal Diseases and Disorders

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (31 May 2021) | Viewed by 7737

Special Issue Editors


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Guest Editor
University of Newcastle School of Medicine and Public Health CALLAGHAN, NSW, AUSTRALIA
Interests: gastrointestinal nutrition; dietary assessment; functional gut disorders

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Guest Editor
University of NewcastleSchool of Medicine and Public HealthNEWCASTLE, NSW, AUSTRALIA
Interests: functional dyspepsia; gastroenterology; gut microbiome

Special Issue Information

Dear Colleagues,

The gastrointestinal (GI) tract exists to process food intake, so it is not surprising that food ingestion is intimately linked to GI disease. However, there remains much to understand about dietary factors in the management of gastrointestinal diseases and disorders. Development of technologies in diagnostics and microbiology, along with rapid advancements in dietary assessment and a changing food environment, combine to create enormous potential for research aimed at improving the management of a wide range of complex and debilitating ‘gut’ conditions.

Dietary intake is strongly implicated in the induction of symptoms of functional gastrointestinal disorders, which are highly prevalent in developed countries and an increasing problem in developing countries. Assessment of both dietary intake and functional gastrointestinal disorder symptoms have historically relied on patient-reported measures, but advancements in dietary intake biomarkers and dietary assessment technologies show potential for improving understanding causal associations between food and induction of symptoms in these disorders.

Emerging evidence suggests gastrointestinal diseases such as coeliac disease, inflammatory bowel diseases, and gastroesophageal reflux overlap with and may be a part of the spectrum of functional disorders such as dyspepsia and irritable bowel syndrome. While the evidence for a gluten-free diet in the dietary management of coeliac disease is well established, many people who do not have coeliac disease are on a gluten-free diet for health reasons, but the risks versus benefits are poorly defined. The exponential increase in the availability of gluten-free foods, and advances in technology for identification and treatment of coeliac disease have implications for dietary management. The influence of diet–microbiome interactions is another fascinating area of discovery, which promises to revolutionize the application of dietary approaches in gut conditions.

In this Special Issue, we will highlight and consolidate emerging evidence in this fascinating and rapidly evolving field by sharing papers that focus on dietary assessment, oral or gut microbiome, novel foods, and new dietary management approaches in common gastrointestinal diseases and disorders.

Original research articles and reviews (systematic reviews and meta-analyses) are welcome.

Dr. Kerith Duncanson
Prof. Nicholas Talley
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Functional gastrointestinal disorder
  • Diet
  • Microbiome
  • Coeliac

Published Papers (2 papers)

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Research

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25 pages, 9782 KiB  
Article
Changes in Fatty Acid Dietary Profile Affect the Brain–Gut Axis Functions of Healthy Young Adult Rats in a Sex-Dependent Manner
by Damian Jacenik, Ana Bagüés, Laura López-Gómez, Yolanda López-Tofiño, Amaia Iriondo-DeHond, Cristina Serra, Laura Banovcanová, Carlos Gálvez-Robleño, Jakub Fichna, Maria Dolores del Castillo, José Antonio Uranga and Raquel Abalo
Nutrients 2021, 13(6), 1864; https://doi.org/10.3390/nu13061864 - 30 May 2021
Cited by 4 | Viewed by 2700
Abstract
Dietary modifications, including those affecting dietary fat and its fatty acid (FA) composition, may be involved in the development of brain–gut axis disorders, with different manifestations in males and females. Our aim was to evaluate the impact of three purified diets with different [...] Read more.
Dietary modifications, including those affecting dietary fat and its fatty acid (FA) composition, may be involved in the development of brain–gut axis disorders, with different manifestations in males and females. Our aim was to evaluate the impact of three purified diets with different FA composition on the brain–gut axis in rats of both sexes. Male and female Wistar rats fed a cereal-based standard diet from weaning were used. At young adult age (2–3 months old), animals were divided into three groups and treated each with a different refined diet for 6 weeks: a control group fed on AIN-93G diet containing 7% soy oil (SOY), and two groups fed on AIN-93G modified diets with 3.5% soy oil replaced by 3.5% coconut oil (COCO) or 3.5% evening primrose oil (EP). Different brain–gut axis parameters were evaluated during 4–6 weeks of dietary intervention. Compared with SOY diet (14% saturated FAs, and 58% polyunsaturated FAs), COCO diet (52.2% saturated FAs and 30% polyunsaturated FAs) produced no changes in brain functions and minor gastrointestinal modifications, whereas EP diet (11.1% saturated FAs and 70.56% polyunsaturated FAs) tended to decrease self-care behavior and colonic propulsion in males, and significantly increased exploratory behavior, accelerated gastrointestinal transit, and decreased cecum and fecal pellet density in females. Changes in FA composition, particularly an increase in ω-6 polyunsaturated FAs, seem to facilitate the development of brain–gut axis alterations in a sex-dependent manner, with a relatively higher risk in females. Full article
(This article belongs to the Special Issue Dietary Management of Gastrointestinal Diseases and Disorders)
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28 pages, 814 KiB  
Review
Dietary Advanced Glycation Endproducts and the Gastrointestinal Tract
by Timme van der Lugt, Antoon Opperhuizen, Aalt Bast and Misha F. Vrolijk
Nutrients 2020, 12(9), 2814; https://doi.org/10.3390/nu12092814 - 14 Sep 2020
Cited by 20 | Viewed by 4206
Abstract
The prevalence of inflammatory bowel diseases (IBD) is increasing in the world. The introduction of the Western diet has been suggested as a potential explanation of increased prevalence. The Western diet includes highly processed food products, and often include thermal treatment. During thermal [...] Read more.
The prevalence of inflammatory bowel diseases (IBD) is increasing in the world. The introduction of the Western diet has been suggested as a potential explanation of increased prevalence. The Western diet includes highly processed food products, and often include thermal treatment. During thermal treatment, the Maillard reaction can occur, leading to the formation of dietary advanced glycation endproducts (dAGEs). In this review, different biological effects of dAGEs are discussed, including their digestion, absorption, formation, and degradation in the gastrointestinal tract, with an emphasis on their pro-inflammatory effects. In addition, potential mechanisms in the inflammatory effects of dAGEs are discussed. This review also specifically elaborates on the involvement of the effects of dAGEs in IBD and focuses on evidence regarding the involvement of dAGEs in the symptoms of IBD. Finally, knowledge gaps that still need to be filled are identified. Full article
(This article belongs to the Special Issue Dietary Management of Gastrointestinal Diseases and Disorders)
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