Special Issue "The Probiotics and Prebiotics and Their Benefits for Health"

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Prebiotics and Probiotics".

Deadline for manuscript submissions: 26 August 2023 | Viewed by 644

Special Issue Editors

School of Food Science and Technology, Jiangnan University, Wuxi 214122, China
Interests: probiotics theory and technology; functional food research and development; gut microbiota and host health
Deep Processing Technology Key Laboratory of Zhejiang Province Animal Protein Food, College of Food and Pharmaceutical Sciences, Ningbo University, Ningbo 315832, China
Interests: regulation of dietary polyphenols on Maillard reaction; evaluation of probiotic effect of polyphenols and regulation of immune metabolism of gut microbiota; food bioactive evaluation
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Special Issue Information

Dear Colleagues,

The goal of this Special Issue, entitled “Probiotics and Prebiotics and their Benefits for Health”, is to focus on the importance of nutrition with probiotics and prebiotics to improve gastrointestinal health in newborns, infants, and children.

Specifically, the aim is to clarify if probiotics and prebiotics can influence gut microbiota composition and host interaction favouring human health and preventing diseases.

There is increasing evidence that dysfunctional micro-ecosystems (e.g., reduced microbial diversity) may be associated with enteritis, such as inflammatory bowel disease, and several parenteral diseases such as obesity, diabetes, liver disease, cardiometabolic complications, and even cancer.

Therefore, understanding the mechanism through which the gut microbiota acts on host metabolism and regulates microbial composition through diet, prebiotics, probiotics, and antibiotics has a significant impact on human health. Most studies are based on infant formula supplemented with prebiotics. No evidence-based data currently exist on the effects of probiotics and/or prebiotics on children's health later in life. Future in-depth studies on the selection of specific prebiotics are still needed, in particular those that use various research means and establish a complete in vitro simulated intestinal system to evaluate the prebiotics and their mechanism on diseases.

Prof. Dr. Qixiao Zhai
Dr. Lianliang Liu
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • prebiotics
  • probiotics
  • gut microbiota
  • metabolites
  • oligosaccharides
  • polysaccharides
  • protein hydrolysates
  • polyphenols
  • metabolic syndrome
  • inflammatory bowel disease

Published Papers (1 paper)

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Anti-Inflammatory and Gut Microbiota Modulating Effects of Probiotic Lactobacillus paracasei MSMC39-1 on Dextran Sulfate Sodium-Induced Colitis in Rats
Nutrients 2023, 15(6), 1388; https://doi.org/10.3390/nu15061388 - 13 Mar 2023
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Probiotics have been shown to possess several properties, depending on the strain. Some probiotics have important roles in preventing infection and balancing the immune system due to the interaction between the intestinal mucosa and cells in the immune system. This study aimed to [...] Read more.
Probiotics have been shown to possess several properties, depending on the strain. Some probiotics have important roles in preventing infection and balancing the immune system due to the interaction between the intestinal mucosa and cells in the immune system. This study aimed to examine the properties of three probiotic strains using the tumor necrosis factor-alpha (TNF-α) inhibition test in colorectal adenocarcinoma cells (Caco-2 cells). It was revealed that the viable cells and heat-killed cells of the probiotic L. paracasei strain MSMC39-1 dramatically suppressed TNF-α secretion in Caco-2 cells. The strongest strains were then chosen to treat rats with colitis induced by dextran sulfate sodium (DSS). Viable cells of the probiotic L. paracasei strain MSMC39-1 reduced aspartate transaminase and alanine transaminase in the serum and significantly inhibited TNF-α secretion in the colon and liver tissues. Treatment with the probiotic L. paracasei strain MSMC39-1 alleviated the colon and liver histopathology in DSS-induced colitis rats. Furthermore, supplementation with probiotic L. paracasei strain MSMC39-1 increased the genus Lactobacillus and boosted the other beneficial bacteria in the gut. Thus, the probiotic L. paracasei strain MSMC39-1 exhibited an anti-inflammation effect in the colon and modulated the gut microbiota. Full article
(This article belongs to the Special Issue The Probiotics and Prebiotics and Their Benefits for Health)
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