The Interplay Between Nutrients and the Intestinal Barrier in Metabolic Liver Diseases: From Bench to Bedside
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".
Deadline for manuscript submissions: closed (25 July 2025) | Viewed by 2540
Special Issue Editors
Interests: gut microbiota; intestinal permeability; metabolic dysfunction-associated steatotic liver disease (MASLD); chronic liver disorders; nutrition; nutrigenetics; nutrigenomics; immunity
Special Issues, Collections and Topics in MDPI journals
Interests: trained immunity; gut microbiota; intestinal permeability; metabolic dysfunction-associated steatotic liver disease (MASLD); chronic liver disorders; nutrition; nutrigenetics; liver cirrhosis; inflammation; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Emerging evidence suggests the crucial role of nutrients and intestinal barrier alteration in the pathogenesis of dysmetabolic chronic liver disorders (CLDs), particularly metabolic dysfunction-associated steatotic liver disease (MASLD).
In the era of precision medicine, nutrigenetic/genomic approaches have progressively shown the active role of nutrients, revealing the mutual relationship between dietary elements and metabolic processes. Relevant findings have identified “pro-inflammatory” foods, elucidating their capability to disrupt immune pathways, ultimately promoting phlogosis and oxidative stress at local, hepatic, and systemic levels. Complementarily, the alteration of the bowel integrity barrier (“leaky gut”), which contributes to the crossing of substances, dramatically impacts this picture. Gut microbiota appears as a key regulator, influencing both nutrient transformation processes and intestinal permeability.
This Special Issue aims to provide new evidence about the complex relationship between gut microbiota, nutrition, and intestinal permeability in MASLD and dysmetabolic CLDs
Special attention will be given to studies elucidating the traits linking nutrients with the intestinal barrier’s homeostasis in this setting.
Manuscript submissions may include original research articles (clinical, translational, or basic research) and systematic reviews.
“From Bench to Bedside”, these studies can provide the basis for designing promising and effective management strategies for MASLD and dysmetabolic CLDs.
Prof. Dr. Alessandro Federico
Dr. Marcello Dallio
Guest Editors
Manuscript Submission Information
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Keywords
- gut microbiota
- intestinal permeability
- metabolic dysfunction-associated steatotic liver disease (MASLD)
- chronic liver disorders
- nutrition
- nutrigenetics
- nutrigenomics
- trained immunity
- liver cirrhosis
- inflammation
- oxidative stress
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