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New Perspectives on Diet and Depression

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: closed (20 May 2025) | Viewed by 672

Special Issue Editor


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Guest Editor
Department of Psychiatry, Teikyo University School of Medicine, Tokyo 173-8605, Japan
Interests: stress; depression; neuropsychiatric diseases; dopamine; diet; micronutrients; L-theanine; ketogenic diet; probiotics
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Special Issue Information

Dear Colleagues,

Evidence has suggested that depressive disorder is significantly associated with dietary habits and nutritional status. Dietary factors such as an excessive intake of energy, skipping breakfast, unhealthy diet styles including the Western diet, a high consumption of ultra-processed food increase individuals’ risk of developing depressive disorder and worsen the course of the illness. Nutritional imbalances such as an inadequate intake of protein, vitamins, minerals, and n-3 polyunsaturated fatty acids also increase the risk of illness. These nutritional imbalances are profoundly related to the biological mechanisms of depressive disorder, i.e., an altered stress response, monoamine deficiency, and chronic low-grade inflammation. It has therefore been found that the supplementation of these nutrients is effective in the protection and treatment of depressive disorder. The gut microbiota and probiotics have also emerged as a novel strategy in the management of depression. Furthermore, many dietary supplements have been shown to ameliorate depressive disorder. As such, this Special Issue aims to provide an overview of recent advances in the field.

Prof. Dr. Hiroshi Kunugi
Guest Editor

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Keywords

  • depressive disorder
  • diet
  • nutrition
  • supplement
  • monoamine
  • inflammation

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Published Papers (1 paper)

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Research

13 pages, 457 KiB  
Article
An Increase of Adropin Can Predict Depression Improvement
by Duška Krnić, Sara Sablić, Maja Marinović Guić, Danijela Budimir Mršić, Dragan Krnić, Romilda Roje, Daniela Šupe Domić and Sanja Lovrić Kojundžić
Nutrients 2025, 17(10), 1666; https://doi.org/10.3390/nu17101666 - 14 May 2025
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Abstract
Objectives Depression is characterized by a lack of energy, social withdrawal, and fatigue, and it is also associated with increased inflammation in the brain. Some studies suggest that adropin may have anti-inflammatory effects and could reduce the inflammatory processes contributing to depression. Methods: [...] Read more.
Objectives Depression is characterized by a lack of energy, social withdrawal, and fatigue, and it is also associated with increased inflammation in the brain. Some studies suggest that adropin may have anti-inflammatory effects and could reduce the inflammatory processes contributing to depression. Methods: We included 54 newly diagnosed patients experiencing their first episode of depression and 56 healthy volunteers in this study. The participants with depression were divided into three subgroups based on DSM-5 and BDI-II criteria. The focus of the study was to compare adropin levels between depressive patients and healthy volunteers, as well as to monitor changes in adropin levels after six months of treatment for depressive patients. Results: Initial measurements showed no significant differences in standard laboratory parameters or adropin levels between the depression and control groups. However, adropin and vitamin D levels increased in the group of depressive patients during the six-month follow-up. Conclusions: Our research indicates that adropin plays a significant role in the development of depression and may influence the effectiveness of depression treatments. Full article
(This article belongs to the Special Issue New Perspectives on Diet and Depression)
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