Special Issue "Systematic Analysis of lncRNA Structures and Functions"
A special issue of Non-Coding RNA (ISSN 2311-553X).
Deadline for manuscript submissions: 31 December 2021.
Interests: bioinformatics; cardiovascular system; circRNA; database; epitranscriptomics; lncRNA; miRNA; non-coding RNA
Special Issues and Collections in MDPI journals
Special Issue in High-Throughput: Microarrays in Non-Coding RNAs Profiling
Special Issue in High-Throughput: Emerging Topics in Epitranscriptomics (RNA Modifications)
Special Issue in Computation: Bioinformatics Tools for ncRNAs
Advances in next-generation sequencing, particularly RNA sequencing (RNA-seq), have led to the discovery of long non-coding RNAs (lncRNAs), whose number surpasses that of protein-coding genes. With the rise of single-cell RNA-seq (scRNA-seq), many cell-type-specific lncRNAs have been identified, yet the functions of lncRNAs remain largely unknown. As proteins have numerous functions, it is natural to assume that a myriad of functions for lncRNAs are waiting to be uncovered. By definition, lncRNAs are non-protein-coding transcripts. Thus, it is essential to examine the sequence structures of lncRNAs to determine the functions of lncRNAs. Currently, there are over 170 known RNA modifications (e.g., A-to-I RNA editing, m6A methylation, and pseudouridylation) that can affect the structures and functions of RNAs, including lncRNAs. This Special Issue on the Systematic Analysis of lncRNA Structures and Functions aims to unravel the diverse functional roles of lncRNAs by focusing on systematic approaches using bioinformatics, computational biology, and/or systems biology approaches coupled with experimental validation.Dr. Shizuka Uchida
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Non-Coding RNA is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- computational biology
- systems biology
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: HiMoRNA: a comprehensive database of human lncRNAs involved in genome-wide epigenetic regulation
Authors: E. Mazurov1; Y.A. Medvedeva1,2
Affiliation: 1 Institute of Bioengineering, Research Center of Biotechnology, Russian Academy of Sciences, Moscow, 117312, Russian Federation 2 School of Biological and Medical Physics, Moscow Institute of Physics and Technology, Dolgoprudny, Moscow Region, 141701, Russian Federation
Abstract: Long non-coding RNAs (lncRNAs) play an important role in genome regulation. Specifically, many lncRNAs interact with chromatin, recruit epigenetic complexes and in this way affect large-scale gene expression programs. However, the experimental data about lncRNA-chromatin interactions is still limited. The majority of experimental protocols do not uncover the mechanics of lncRNA-based genome-wide epigenetic regulation. Here we present HiMoRNA (Histone-Modifying RNA) database, a resource containing correlated lncRNA–epigenetic changes in specific genomic locations genome-wide. HiMoRNA integrates a large amount of multi-omics data to characterize the effects of lncRNA on epigenetic modifications and gene expression. The current release of HiMoRNA includes more than 5 million associations in humans for 10 histone modifications in multiple genomic loci and 4145 lncRNA. HiMoRNA provides a user-friendly interface to facilitate browsing, searching and retrieving of lncRNAs associated with epigenetic profiles of various chromatin loci. We believe that HiMoRNA is a convenient and valuable resource that can greatly facilitate functional annotation of lncRNAs.