Secondary Structural Model of MALAT1 Becomes Unstructured in Chronic Myeloid Leukemia and Undergoes Structural Rearrangement in Cervical Cancer
Abstract
:1. Introduction
2. Results and Discussion
2.1. DMS-Seq Data Suggest Unfolding of MALAT1 Structure in K562 Cells
2.2. Predicted Secondary Structural Changes in K562-MALAT1 Would Impact Multiple RNA- and Protein-Binding Sites
2.3. PARIS Data Suggest Maintenance of Overall Structure of MALAT1 with Rearrangements of Select Long-Range Interactions
2.4. Predicted Structural Changes in HeLa-MALAT1 Would Impact RNA-Binding Sites and Modifications
3. Materials and Methods
3.1. Dataset Acquisition
3.2. Dataset Analysis and Comparison to MALAT1 Secondary Structural Model
3.3. Data and Software Availability
4. Conclusions
Supplementary Materials
Author Contributions
Funding
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Wang, M.C.; McCown, P.J.; Schiefelbein, G.E.; Brown, J.A. Secondary Structural Model of MALAT1 Becomes Unstructured in Chronic Myeloid Leukemia and Undergoes Structural Rearrangement in Cervical Cancer. Non-Coding RNA 2021, 7, 6. https://doi.org/10.3390/ncrna7010006
Wang MC, McCown PJ, Schiefelbein GE, Brown JA. Secondary Structural Model of MALAT1 Becomes Unstructured in Chronic Myeloid Leukemia and Undergoes Structural Rearrangement in Cervical Cancer. Non-Coding RNA. 2021; 7(1):6. https://doi.org/10.3390/ncrna7010006
Chicago/Turabian StyleWang, Matthew C., Phillip J. McCown, Grace E. Schiefelbein, and Jessica A. Brown. 2021. "Secondary Structural Model of MALAT1 Becomes Unstructured in Chronic Myeloid Leukemia and Undergoes Structural Rearrangement in Cervical Cancer" Non-Coding RNA 7, no. 1: 6. https://doi.org/10.3390/ncrna7010006