Special Issue "Macromolecules and Nanomaterials: Their Impact on Nanomedicine"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: closed (30 November 2018)

Special Issue Editors

Guest Editor
Prof. Dr. Juan M. Ruso

Soft Matter and Molecular Biophysics Group, Department of Applied Physics, University of Santiago de Compostela, E-15782 Santiago de Compostela, Spain
Website | E-Mail
Interests: synthesis and characterization of nanostructured templated materials and the biophysics of proteins and ligand-protein interactions; complexation of different proteins with amphiphilic ligands (surfactants, lipids and drugs)
Guest Editor
Dr. Natalia Hassan

Programa Institucional de Fomento a la I+D+i Universidad Tecnológica Metropolitana, Santiago-Chile
E-Mail
Interests: polymer chemistry; materials chemistry and nanotechnology

Special Issue Information

Dear Colleagues,

Biomacromolecule structures have been studied in several publications; nevertheless, some interactions have not been studied deeply in the context of medicine. In this scenario, soft materials can interact with several different biomacromolecules (proteins, phospholipids, organelles, biological fluid, etc.) starting a competition of these biological molecules with material surface altering biological systems. New computational and experimental techniques have been explored in recent years to answer different questions that have not yet been solved. Biosensors, tissue engineering, microfluidics, and so on are some new perspective to be studied in this topic. In this Special Issue, we would like to demonstrate that new soft materials can completely change biomacromolecule structures, giving potential information on the clearance, immune response, biodistribution, metabolism and their biocompatibility, inducing their final bioapplication.

Prof. Dr. Juan M. Ruso
Dr. Natalia Hassan
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • Bionanomaterials
  • Bioinspired nanostructures
  • Microfluidic devices
  • Hydrogels and microgels
  • Biocomposite materials
  • Protein nanoparticles
  • Nanocapsules for drug delivery

Published Papers (1 paper)

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Research

Open AccessArticle Designed Functional Dispersion for Insulin Protection from Pepsin Degradation and Skeletal Muscle Cell Proliferation: In Silico and In Vitro Study
Nanomaterials 2018, 8(10), 852; https://doi.org/10.3390/nano8100852
Received: 10 September 2018 / Revised: 12 October 2018 / Accepted: 17 October 2018 / Published: 19 October 2018
Cited by 1 | PDF Full-text (1477 KB) | HTML Full-text | XML Full-text | Supplementary Files
Abstract
Functionalized single-walled carbon nanotubes with polyethylene glycol (PEGylated SWCNTs) are a promising nanomaterial that recently has emerged as the most attractive “cargo” to deliver chemicals, peptides, DNA and RNAs into cells. Insulin therapy is a recommended therapy to treat diabetes mellitus despite its [...] Read more.
Functionalized single-walled carbon nanotubes with polyethylene glycol (PEGylated SWCNTs) are a promising nanomaterial that recently has emerged as the most attractive “cargo” to deliver chemicals, peptides, DNA and RNAs into cells. Insulin therapy is a recommended therapy to treat diabetes mellitus despite its side effects. Recently, functional dispersion made up of bioactive peptides, bioactive compounds and functionalized carbon nanomaterials such as PEGylated SWCNTs have proved to possess promising applications in nanomedicine. In the present study, molecular modeling simulations are utilized to assist in designing insulin hormone-PEGylated SWCNT composites, also called functional dispersion; to achieve this experimentally, an ultrasonication tool was utilized. Enzymatic degradation assay revealed that the designed functional dispersion protects about 70% of free insulin from pepsin. In addition, sulforhodamine B (SRB) assay, the quantification of insulin and glucose levels in differentiated skeletal muscle cell supernatants, reveals that functional dispersion regulates glucose and insulin levels to promote skeletal muscle cell proliferation. These findings offer new perspectives for designed functional dispersion, as potential pharmaceutical preparations to improve insulin therapy and promote skeletal muscle cell health. Full article
(This article belongs to the Special Issue Macromolecules and Nanomaterials: Their Impact on Nanomedicine)
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