Special Issue "Microscopy for Nanomedicine Research"
A special issue of Nanomaterials (ISSN 2079-4991).
Deadline for manuscript submissions: 30 November 2020.
Department of Electronics and Biomedical Engineering, Faculty of Physics, Universitat de Barcelona, Barcelona, Spain.
Interests: nanomedicine; drug delivery; super resolution microscopy; electron microscopy; peptide chemistry
Nanomedicine arose 20 years ago with the promise to selectively deliver drugs at target sites, increasing their effectivity while minimizing undesired side effects. However, despite the great promise behind nanomedicine for drug delivery, very few products have been approved for patient use.
Different advanced microscopy techniques can guide in the path to find effective nanomedicines. From the robust characterization of nanomaterials to nanomaterials’ interaction with biological fluids and how they finally reach the target cell and organelle, microscopy can give information in each of these steps.
The potential information on nanomaterials that could be obtained from microscopy is very diverse: structure, morphology, size, surface roughness, surface charge, total number of ligands/particle, functional ligands/particle, atomic composition, etc.
Not only right after the nanomaterial formulation, but also on nanomaterial’s performance, microscopy can give important information. Protein corona formation, the EPR effect, transcytosis, extravasation, cellular targeting or the intracellular pathway of nanomedicines are some of the phenomena that can be studied using microscopy. Further, the stability of nanoformulation on different steps can potentially be followed, too.
Moreover, functional microscopy transcends pure structural information unveiling physical, chemical, and optical properties. Functional parameters like enzymatic activity, polarity, charge, pH, etc. of nanomaterials’ performance can be obtained with different microscopy techniques.
Finally, correlative techniques, usually applied to study biological processes, are starting to be used for nanomedicine.
Thus, microscopy no longer gives just a “photography” of the nanomaterial in time and space, but multidimensional information valuable for a robust nanomaterial characterization and to design more efficient nanomedicines.
Additionally, all the microscopy techniques applied for nanomedicine can also be used for nanotheranostic purposes.
The Special Issue of Nanomaterials will cover the aforementioned advances in different advanced microscopy techniques to be applied in nanomedicine.
Dr. Sílvia Pujals
Manuscript Submission Information
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- Drug delivery
- Light microscopy
- Confocal laser scanning microscopy
- Super resolution microscopy
- In vivo optical imaging
- Electron microscopy
- Atomic force microscopy
- Correlative microscopy
- Functional microscopy