Special Issue "Isotopes Labeled Nanoparticles"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 20 January 2021.

Special Issue Editors

Prof. Aleksander Bilewicz
Guest Editor
Institute of Nuclear Chemistry and Technology, Warsaw, Warsaw, Poland
Interests: nuclear chemistry; radiopharmacy; alpha and Auger electron emitters in nuclear medicine; PET radiopharmaceuticals; radionuclide labelled nanoparticles; relativistic effects in chemistry; transactinide chemistry
Dr. Penelope Bouziotis
Co-Guest Editor
Radiochemical Studies Laboratory, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, National Center for Scientific Research "Demokritos, Athens, Greece
Interests: nanoparticles; theranostics; PET/SPECT/MR Imaging; radiolabeled nanoparticles; nanobrachytherapy
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Special Issue Information

Dear Colleagues,

Recently, there has been an increasing amount of interest in nanomaterials for diagnostic and therapeutic applications. Radionuclides with specific emission properties can be incorporated into nanoparticles (NPs) and used for radionuclide therapy and radio-imaging. The advantage of NPs is their potential for containing several radioactive atoms within a single carrier. NPs can deliver radionuclides using either passive or active targeting strategy. The passive targeting accumulation of NPs takes place in nonspecific ways through enlarged gap junctions in tumor endothelial cells. This type of targeting, which enables macromolecules to selectively accumulate in the tumor tissue, is called enhanced permeation and retention (EPR). Unfortunately, local drug deposition is unfeasible for larger tumors with poor vascularization and for floating cancers such as lymphoma and leukemia. Target specificity is then achieved through hybrid NPs produced by conjugating NPs with tumor-specific biomolecules, including mAbs, aptamers, peptides, or various receptor-specific substrates. Recently, there has been a growing interest in the use of radionuclide-labeled nanoparticles to directly deliver corpuscular radiation to the tumor, such as in brachytherapy; thus, such technology using nanoparticles is called nanobrachytherapy. In this perspective, radioactive nanoparticles could represent a promising alternative to current brachytherapy methods with outstanding results compared to conventional brachytherapy.

Prof. Aleksander Bilewicz
Dr. Penelope Bouziotis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Radiopharmacy
  • Radionuclides
  • Radiolabeled nanoparticles
  • PET imaging
  • Radioimmunotherapy

Published Papers

This special issue is now open for submission.
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