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Nanomaterials
Special Issues
Recent Advances in Nanoscale Detection for Biomedical Imaging and Analysis
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Recent Advances in Nanoscale Detection for Biomedical Imaging and Analysis

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 26 January 2026 | Viewed by 614

Special Issue Editors

Dr. Anthony A. Fung

E-Mail Website
Guest Editor
Department of Biomedical Engineering, Yale University, New Haven, CT 06520, USA
Interests: spatial multi-omics; digital pathology; immune aging; cellular senescence
Dr. Xinyu Chen

E-Mail Website
Guest Editor Assistant
Howard Hughes Medical Institute (HHMI), University of California San Diego, La Jolla, CA, USA
Interests: Imaging flow cytometry; neuroscience; appetite control

Special Issue Information

Dear Colleagues,

It is often the case in science that the closer we zoom in, the clearer the big picture becomes. At the nanoscale, examining processes such as small molecule trafficking, precise optical detection, and material surface enhancements can reveal significant insights into biological mechanisms at the physiological level. Nanoscale compounds and detection methods have continuously evolved, offering unprecedented sensitivity, resolution, and specificity critical to advancements in biomedical imaging and analytical technologies.

This Special Issue of Nanomaterials, titled ‘Recent Advances in Nanoscale Detection for Biomedical Imaging and Analysis’, aims to showcase cutting-edge research emphasizing the vital role of nanomaterials in biomedical contexts. We seek to highlight innovative applications and developments in small molecules exhibiting unique physiological accessibility, nanostructured surfaces and particles that extend detection limits, advanced image processing algorithms that enhance spatial resolution, and nanoscale devices that possess unique operational characteristics.

Whether pushing the limits of ultrafast laser pulses, lowering the molecular detection limit, developing novel contrast agents, or enhancing molecular specificity, we cordially invite submissions of original research articles, comprehensive reviews, and perspectives that illustrate the transformative power and versatility afforded by nanoscale technologies in biomedical imaging and analysis. Topics of particular interest include, but are not limited to, the following:

  • Nanoparticle/surface-enhanced imaging modalities;
  • Single-molecule detection technologies and their biomedical applications;
  • Nanophotonic or biosensors for improved sensing and imaging;
  • Novel imaging probes and contrast agents;
  • Novel image processing algorithms for spatial resolution enhancement;
  • Nanodevices and nanoengineered materials for physiological interfacing.

We look forward to receiving your outstanding contributions and pushing the boundaries of biomedical imaging and analysis through nanotechnology together.

Dr. Anthony A. Fung
Guest Editor

Dr. Xinyu Chen
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoscopy
  • bionanophotonics
  • small molecules
  • single-molecule detection
  • contrast agents and probes
  • super-resolution imaging
  • nano-spectroscopy

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

19 pages, 5895 KiB  
Article
Receptor-Mediated SPION Labeling of CD4+ T Cells for Longitudinal MRI Tracking of Distribution Following Systemic Injection in Mouse
by Yu Ping, Songyue Han, Brock Howerton, Francesc Marti, Jake Weeks, Roberto Gedaly, Reuben Adatorwovor and Fanny Chapelin
Nanomaterials 2025, 15(14), 1068; https://doi.org/10.3390/nano15141068 - 10 Jul 2025
Viewed by 436
Abstract
Tracking T cells in vivo using MRI is a major challenge due to the difficulty of labeling these non-phagocytic cells with a sufficient contrast agent to generate a detectable signal change. In this study, we explored CD4-Superparamagnetic iron oxide nanoparticles (SPION), which is [...] Read more.
Tracking T cells in vivo using MRI is a major challenge due to the difficulty of labeling these non-phagocytic cells with a sufficient contrast agent to generate a detectable signal change. In this study, we explored CD4-Superparamagnetic iron oxide nanoparticles (SPION), which is commonly used in magnetic cell sorting, as a potential receptor-mediated, specific CD4+ T cell MRI labeling agent. We optimized the labeling protocol for maximal CD4+ cell labeling and viability. Cell health was confirmed with trypan blue assay, and labeling efficacy was confirmed with Prussian blue staining, transmission electron microscopy, and MRI of labeled cell pellets. Key cell functionality was assessed by flow cytometry. Next, CD4-SPION-labeled T cells or unlabeled T cells were delivered via intravenous injection in naïve mice. Liver MRIs pre-, 24 h, and 72 h post-T cell injection were performed to determine in vivo tracking ability. Our results show that CD4-SPION induces significant attenuation of T2 signals in a concentration-dependent manner, confirming their potential as an effective MRI contrast agent. In vitro, analyses showed that CD4+ T cells were able to uptake CD4-SPION without affecting cellular activity and key functions, as evidenced by Prussian blue staining and flow cytometric analysis of IL-2 receptor and the IL-7 receptor α-chains, CD69 upregulation, and IFN-γ secretion. In vivo, systemically distributed CD4-SPION-labeled T cells could be tracked in the liver at 24 and 72 h after injection, contrary to controls. Histological staining of tissue sections validated the findings. Our results showed that SPION CD4+ T cell sorting coupled with longitudinal MR imaging is a valid method to track CD4+ T cells in vivo. This safe, specific, and sensitive approach will facilitate the use of SPION as an MRI contrast agent in clinical practice, allowing for non-invasive tracking of adoptive cell therapies in multiple disease conditions. Full article
(This article belongs to the Special Issue Recent Advances in Nanoscale Detection for Biomedical Imaging and Analysis)
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