Special Issue "Frontiers in Nanotoxicology"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 30 November 2020.

Special Issue Editor

Dr. Alexander Gusev
Website1 Website2
Guest Editor
1) National University of Science and Technology "MISIS", Moscow 119991, Russia
2) Derzhavin Tambov State University, Tambov 392000, Russia
Interests: nanotoxicology; plant nanobiotechnology; antibacterial nanomaterials; carbon nanomaterials; bioaccumulation of nanoparticles

Special Issue Information

Dear Colleagues,

Nanotoxicology is an arising discipline interested in characterizing and categorizing the adverse effects induced by nanomaterials for determining relationships of structure and function between nanoparticles and toxicity. The application of nanotechnology is one of the fastest growing areas of materials science, but the applied research in nanotechnology is ahead of nanotoxicological research. However, the safety assessment should be carried out in parallel with the development of new materials (safe-by-design).

This Special Issue will combine scientific articles and reviews devoted to such problems of nanotoxicology as the biological effects of both widely known and emerging nanomaterials (for example, 2D transition metal chalcogenides, MXenes, perovskites, etc.), the effects of nanoparticle size, geometry and surface properties on toxicity and dose-response relationships, cell and molecular mechanisms of nanotoxicity, environmental toxicology of nanomaterials, research of nano-bio interfaces, new research methods for nanotoxicology and nanomedicine, predictive and personalized nanotoxicology. Works based on an interdisciplinary approach regarding new biomedical nanomaterials are also welcomed.

Dr. Alexander Gusev
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • nanomaterials
  • nanoparticles
  • nanotechnology
  • nanotoxicology
  • nanomedicine
  • dose-response
  • nano-bio interface

Published Papers (1 paper)

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Open AccessArticle
Comparison of the Level and Mechanisms of Toxicity of Carbon Nanotubes, Carbon Nanofibers, and Silicon Nanotubes in Bioassay with Four Marine Microalgae
Nanomaterials 2020, 10(3), 485; https://doi.org/10.3390/nano10030485 - 08 Mar 2020
Cited by 2
Nanoparticles (NPs) have various applications in medicine, cosmetics, optics, catalysis, environmental purification, and other areas nowadays. With an increasing annual production of NPs, the risks of their harmful influence to the environment and human health is rising. Currently, our knowledge about the mechanisms [...] Read more.
Nanoparticles (NPs) have various applications in medicine, cosmetics, optics, catalysis, environmental purification, and other areas nowadays. With an increasing annual production of NPs, the risks of their harmful influence to the environment and human health is rising. Currently, our knowledge about the mechanisms of interaction between NPs and living organisms is limited. Additionally, poor understanding of how physical and chemical characteristic and different conditions influence the toxicity of NPs restrict our attempts to develop the standards and regulations which might allow us to maintain safe living conditions. The marine species and their habitat environment are under continuous stress due to anthropogenic activities which result in the appearance of NPs in the aquatic environment. Our study aimed to evaluate and compare biochemical effects caused by the influence of different types of carbon nanotubes, carbon nanofibers, and silica nanotubes on four marine microalgae species. We evaluated the changes in growth-rate, esterase activity, membrane polarization, and size changes of microalgae cells using flow cytometry method. Our results demonstrated that toxic effects caused by the carbon nanotubes strongly correlated with the content of heavy metal impurities in the NPs. More hydrophobic carbon NPs with less ordered structure had a higher impact on the red microalgae P. purpureum because of higher adherence between the particles and mucous covering of the algae. Silica NPs caused significant inhibition of microalgae growth-rate predominantly produced by mechanical influence. Full article
(This article belongs to the Special Issue Frontiers in Nanotoxicology)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Comparison of the Level and Mechanisms of Toxic Effects of Carbon and Silicon Nanoparticles in Bio-Testing on Four Types of Marine Microalgae
Authors: Pikula K.S.1, Chayka V.V.1, Zakharenko A.M.1, Markina Zh.V.1,2, Vedyagin A.A.3, Kuznetsov V.L.3, Gusev A.A.4, Park S.5, Golokhvast K.S.1,6,7
Affiliation: 1 Far Eastern Federal University, Vladivostok, Russian Federation 2 Zhirmunsky National Scientific Center of Marine Biology, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, , Russian Federation 3 Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation 4 Tambov State University, Tambov, Russian Federation 5 Inha University, Incheon, South Korea 6 Pacific Geographical Institute, Far Eastern Branch of the Russian Academy of Sciences, Vladivostok, Russian Federation 7 N.I. Vavilov All-Russian Institute of Plant Genetic Resources, Sankt-Peterburg, Russian Federation
Abstract: The aim of this study was to determine the level and characteristics of toxic effects of carbon nanotubes, carbon nanofibres and silicon nanotubes by comparing the morphological and biochemical cell changes of four types of marine microalgae. CNT-1 and CNT-2 had non-significant toxic effect on the growth rate of all four species of microalgae but caused a high inhibition of esterase activity and depolarization of cell membranes, which may be influenced by heavy metals and other impurities in nanoparticles. Probably, a higher impact of the CNT-1 and CNF-1 samples in comparison with CNT-2 and CNF-2 is associated with less ordered structure, material defects and amorphous carbon, which indicates predominance of mechanical damage as a mechanism of toxicity. SNT-1 and SNT-2 did not affect the esterase activity and membrane potential of microalgae cells of all studied species even at higher concentrations, which indicates predominance of mechanical damage as a mechanism of toxicity.

Title: Water-soluble Carbon Quantum Dots Modified by Amino Groups for Polarization Fluorescence Detection of Copper (II) Ion in Aqueous Media
Authors: Anastasia Yakusheva1,*, Denis Kuznetsov1, Sergei Eremin2, Dmitry Muratov1, Feruza Tuyakova1
Affiliation: 1 Department of Functional Nanosystems and High-Temperature Materials, National University of Science and Technology MISIS, 119049, Leninsky prospect 4, Moscow, Russia 2 Faculty of Chemistry, M. V. Lomonosov Moscow State University, 119991, Lenin's mountains, Moscow, Russia
Abstract: Manufacture development is a problem which changing environment and natural water composition, especially near cities and industrial areas. Hence, the quality and quantity of water source is demanding precisely control. The innovative method of polarization fluorescence analysis (PFA) has been developed to measure heavy metal concentration in water. The approach promises a decreased exploring time, an enhanced measurement efficiency, and is basic for high-precision tests. As a main result, the new type of CQD with controllable fluorescence properties and functionalized amino – groups, is appropriate for polarization fluorescent measurements, was investigated here. The two-steps microwave synthesis route adjusted wavelength and fluorescence intensity of carbon quantum dots (CQD). In particular, the PFA allowed measurements concentration of copper (II) cations in water samples below acceptable values. Moreover, in comparison with the fluorescence quenching route, polarization fluorescence provides a convenient, simple and fast application for effective water safety analysis.

Authors: A.A. Kudrinskiy1,2, G.V. Lisichkin1, Jaeho Pyee3, A.A. Gusev4, O.A. Shapoval5, and Yu.A. Krutyakov1,2
Affiliation: 1 Department of Chemistry, Lomonosov Moscow State University, 1-3 Lenin Hills, Moscow, 119991, Russia 2 National Research Center “Kurchatov Institute”, Akademika Kurchatova pl. 1, Moscow, 123182, Russia 3 Department of Molecular Biology & Institute of Nanosensor and Biotechnology, Dankook University, Chungnam, South Korea 5 Pryanishnikov Russian Scientific Research Institute of Agrochemistry, 31a, Pryanishnikova str., Moscow, 127550, Russia
Abstract: Dispersions of silver nanoparticles stabilized with a wide array of surfactants and polymers were used as examples for quantitative evaluation of whether the various measurable properties of silver nanoparticles fit as descriptors of linear QNAR (Quantitative Nanostructure-Activity Relationship) models for silver nanoparticles toxicity evaluation. It has been shown that QNAR models should be based on descriptors such as the nanoparticle charge and the colloidal stability. A new descriptor has been proposed for the integral characterization of the silver dispersion colloidal stability. According to the obtained data, it can be considered applicable for building QNAR models of higher efficacy. It has also been shown that the particle size traditionally used as a descriptor is lacking in significance compared to the dispersion stability properties.

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