Special Issue "Electrospinning Nanofibers: Synthesis and Applications"

A special issue of Nanomaterials (ISSN 2079-4991).

Deadline for manuscript submissions: 25 July 2020.

Special Issue Editor

Prof. Jen-Chang Yang
Guest Editor
Taipei Medical University, Taipei, Taiwan
Interests: Dental Materials; Nanomaterials; Medical Devices; Recombinant Spider Silks; Translational Researches

Special Issue Information

Dear Colleagues,

Electrospinning is a modern and efficient method which uses an electric field to produce fine fibers of a diameter down to nanoscale even with milligrams of materials. It encompasses the utilization of various small molecules/biomolecules, synthetic or natural polymers, ceramics, or their combinations/composites for nanofiber production at a mass scale. Fiber-shaped nanostructures with a tunable porosity, high specific surface area, and a flexibility of functionalization with biological molecules are its advantages. These spun fibers have wide applications in industry and biomedical areas, such as energy, catalysis, water treatment, aerospace, batteries, sensors, and electronic devices, filtration, composites, would dressing, tissue engineering scaffolds, and drug delivery. This Special Issue aims to enclose the most innovative advancements in the field of electrospinning of materials and fabrication processes. Furthermore, this may serve as a potent platform for knowledge sharing on the advancements in novel technologies and applications.

Prof. Jen-Chang Yang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Mechanical properties of electrospun 50:50 Fibrinogen:PCL nanofibers
Authors: Martin Guthold
Affiliation: Wake Forest University, Winston Salem, United States
Abstract: Electrospun nanofibers manufactured from biocompatible materials may be useful for numerous bioengineering applications, such as tissue engineering, creating organoids or dressings, and drug delivery. In many of these applications the morphological and mechanical properties of the materials at the macro- and microscale (single fiber level) are important elements affecting their function. We used a combined atomic force microscope/optical microscope technique to determine the mechanical properties of nanofibers that were electrospun from a 50:50 fibrinogen:PCL mixture. Both of these materials are widely available, biocompatible and relatively inexpensive. Fibers were spun onto a striated substrate with 6 micrometer wide grooves, anchored with epoxy on the ridges and pulled with the tip of an atomic force microscope. We provide the technical details and equations of these lateral force pulling experiments. The blended fibers show strong strain softening, as the modulus decreases from an initial value of 1700 MPa at 5-10% strain to a value of 110 MPa at values above 40% strain. Despite this extreme strain softening, these blended fibers are rather extensible, as they can be strained to about 2 times their initial length before breaking. The fibers exhibited high energy loss (up to 70%), and strains larger than 5% permanently deformed the fiber. The 50:50 PCL:Fibrinogen fibers display the stress-strain curves of a ductile material. We provide a comparison of the mechanical properties of these blended fibers with other electrospun and natural nanofibers.

Title: The nanomechanical properties of single, electrospun collagen/fibrinogen fibers
Authors: Martin Guthold; Stephen Baker
Affiliation: Wake Forest University, Winston Salem, United States
Abstract: The goal of tissue engineered scaffolds is to provide a biological substitute for failing tissues, restoring and maintaining tissue function. Using electrospun protein fibers as tissue engineering scaffolds is a promising solution to this difficult problem. Collagen is the most widely used and studied electrospun protein due to its excellent biocompatibility, but it lacks the structural and mechanical integrity that is needed for many applications. Electrospun fibrinogen has recently come to the forefront of the field with mechanical properties much better than electrospun collagen fibers. For this study, we blended collagen and fibrinogen in a 1:1 ratio to make a hybrid fiber. Using a combined atomic force microscopy (AFM)/Optical microscopy technique, we were able to determine key mechanical properties of individual electrospun collagen/fibrinogen fibers under dry and hydrated conditions. We showed that dry collagen/fibrinogen fibers can be extended to 84% of their original length while hydrated fibers can be extended to 198% of their original length, all before breaking. Permanent deformation for the fibers does not occur until 26-38% strain or 74-113% strain for dry and hydrated fibers respectively. These fibers also exhibited a total and relaxed or elastic modulus. For dry samples the average relaxed modulus was 387 MPa while the average total modulus was 488 MPa. Hydrated samples were an order of magnitude lower at 40 MPa and 68 MPa for relaxed and total modulus respectively. We also determined the energy loss with increasing strain.

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