Nanomaterials for Matrix-Free Laser Desorption/Ionization Mass Spectrometry
A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Nanophotonics Materials and Devices".
Deadline for manuscript submissions: 18 August 2025 | Viewed by 551
Special Issue Editors
Interests: dairy products; bioactive food-derived proteins; food processing; microorganism studies; antimicrobial agents; plasmonic systems; NALDI-TOF-MS; functional nanoparticles; fuels
Special Issues, Collections and Topics in MDPI journals
Interests: MALDI; SALDI; nanoparticles; mass spectrometry; metabolites
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Laser desorption/ionization (LDI) is one of the most popular ionization techniques currently used in mass spectrometry (MS). This technique is most commonly used in a variant of matrix-assisted laser desorption/ionization (MALDI), which uses a low-molecular-weight organic acid mixed with the sample to support the ionization process. However, this approach has some shortcomings, such as a high chemical background in the spectral region below an m/z of 700, making it difficult to analyze compounds giving signals in this spectral region, and inhomogeneous co-crystallization of analyte and matrix leading to the formation of so-called “sweet spots”, i.e., an inhomogeneous distribution of the analyte in the crystallizing matrix. For these reasons, increasing research attention is focused on the possibilities offered by the use of matrix-free systems based on nanostructures in laser methods, which are referred to as surface-assisted laser desorption/ionization (SALDI). The use of nanostructures in LDI MS has made it possible to analyze low molecular compounds, often at very low concentrations, without the presence of a matrix-derived chemical background, contributing to more applications of the LDI MS method.
In this Special Issue, we will discuss the latest information on the use of nanoparticles and nanostructures in matrix-free laser desorption/ionization mass spectrometry techniques.
Dr. Paweł Piotr Pomastowski
Dr. Adrian Arendowski
Guest Editors
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Keywords
- laser desorption/ionization
- MALDI
- mass spectrometry
- NALDI
- nanomaterials
- SALDI
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