Metal Nanostructures in Biological Applications

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: 20 January 2026 | Viewed by 3197

Special Issue Editors


E-Mail Website
Guest Editor
National Center for Innovative Technologies in Public Health, Istituto Superiore Di Sanita, Rome, Italy
Interests: nanomaterials; biomaterial; physicochemical characterization; risk assessment; nanomaterial–cell interaction; innovative antimicrobial therapies and nanotechnologies

E-Mail Website
Guest Editor
National Center for Innovative Technologies in Public Health, Italian National Institute of Health, Rome, Italy
Interests: microbiology; bacterial and viral infections; host–cell interactions; nanomaterials; nanomaterial risk assessment; innovative antimicrobial drugs; drug delivery; natural antimicrobial compounds
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Metal nanostructures represent a category of particularly appealing materials due to their physico-chemical properties, such as size, shape, aspect ratio, surface area, surface charge, chemical composition, and surface reactivity, which determine enhanced optical, catalytic, mechanical, magnetic, and antibacterial properties or completely new characteristics. These specific and intrinsic properties, along with the engineering ability to modify their surface to carry antibodies, peptides, and other agents, have made these materials attractive for application in drug and gene delivery, cancer therapy, biomedical imaging, tissue engineering, infectious disease treatment, and oral and skin infection.

Synthesis methodologies to produce metal nanostructures play a key role in determining physico-chemical properties, as well as their biomedical application. However, toxicological studies have shown that some metallic nanoparticles can be toxic. Biological methods, such as green synthesis that uses plant extracts and microorganisms, represent a sustainable, alternative approach to producing biocompatible metal nanostructures. The merging of nanomaterials with biomaterials, such as polymeric hydrogel, or other technologies, such as 3D printing, allows us to develop innovative approaches for biomedicine.

This Special Issue intends to present the current strategies to design and develop innovative tools based on biocompatible metal nanostructures for biomedical applications. We cordially invite you to publish your research in this issue.

Dr. Barbara De Berardis
Dr. Maria Grazia Ammendolia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metal nanostructure synthesis and surface modifications
  • green synthesis
  • drug delivery
  • biomedical imaging
  • anti-infective treatments
  • neurodegenerative diseases
  • tissue engineering
  • wound healing
  • 3D printing
  • risk assessment

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Order results
Result details
Select all
Export citation of selected articles as:

Research

25 pages, 4125 KB  
Article
Enhanced Killing of Colon Cancer Cells by Mesoporous Silica Nanoparticles Loaded with Ellagic Acid
by Khaled AbouAitah, Amr Nassrallah, Ahmed A. F. Soliman, Anna Swiderska-Sroda, Tadeusz Chudoba, Julita Smalc-Koziorowska, Beom Soo Kim and Witold Łojkowski
Nanomaterials 2025, 15(20), 1547; https://doi.org/10.3390/nano15201547 - 10 Oct 2025
Viewed by 639
Abstract
Background: Natural compounds, including ellagic acid (ELG), are promising anticancer agents with low adverse effects. In this paper, we test in vitro the effectiveness of mesoporous silica nanoparticles (MSN) as an ELG carrier against colon cancer. Methods: We produced MSNs functionalized with triptycene [...] Read more.
Background: Natural compounds, including ellagic acid (ELG), are promising anticancer agents with low adverse effects. In this paper, we test in vitro the effectiveness of mesoporous silica nanoparticles (MSN) as an ELG carrier against colon cancer. Methods: We produced MSNs functionalized with triptycene (TRP) and loaded with ELG, further called MSNTRPELG nanoformulation. The nanoformulation contained over 11 wt.% TRP and approximately 25 wt.% ELG in the mesoporous structure and on the surface of particles. It was assessed for anticancer effects against two colon cancer cells: HCT-116 and HT-29 for treatment with up to 200 µM. Results: Comparing to free ELG, we have shown a three times higher cancer inhibition. The lowest IC50 values were for HCT-116 (88.1 ± 0.1 µM) and HT-29 (77.6 ± 0.1 µM). When treated with free ELG, the values were 187.1 ± 0.1 µM and 300.0 ± 0.1 µM, respectively. MSNTRPELG enhanced apoptosis primarily by activating caspase-3, p53, and Bax while downregulating Bcl-2 in HCT-116 and HT-29 cells. It also inhibited receptor tyrosine kinases (HER2 and VEGFR2). Preliminary Western blot observations suggest suppression of B-RAF, C-RAF, and K-RAS oncogenes, with stronger inhibition by the nanoformulation than by free ELG. Conclusions: This work highlights the potential of MSNs to enhance the efficacy of natural prodrugs, particularly ELG, in cancer therapy. Full article
(This article belongs to the Special Issue Metal Nanostructures in Biological Applications)
Show Figures

Graphical abstract

25 pages, 3514 KB  
Article
Harnessing Stevia rebaudiana for Zinc Oxide Nanoparticle Green Synthesis: A Sustainable Solution to Combat Multidrug-Resistant Bacterial Pathogens
by Mohamed Tharwat Elabbasy, Rasha M. El Bayomi, Esraa A. Abdelkarim, Abd El-Salam E. Hafez, Mohamed S. Othman, Mohamed E. Ghoniem, Mai A. Samak, Muteb H. Alshammari, Fahad Awwadh Almarshadi, Tamer Elsamahy and Mohamed A. Hussein
Nanomaterials 2025, 15(5), 369; https://doi.org/10.3390/nano15050369 - 27 Feb 2025
Cited by 4 | Viewed by 2074
Abstract
The rise of multidrug-resistant (MDR) bacteria in food products poses a significant threat to public health, necessitating innovative and sustainable antimicrobial solutions. This study investigates the green synthesis of zinc oxide nanoparticles (ZnO-NPs) using Stevia rebaudiana extracts to evaluate their antibacterial and antibiofilm [...] Read more.
The rise of multidrug-resistant (MDR) bacteria in food products poses a significant threat to public health, necessitating innovative and sustainable antimicrobial solutions. This study investigates the green synthesis of zinc oxide nanoparticles (ZnO-NPs) using Stevia rebaudiana extracts to evaluate their antibacterial and antibiofilm activities against MDR Staphylococcus aureus strains isolated from sold fish samples. The obtained results show that the contamination with S. aureus reached 54.2% in the tested fish samples (n = 120), underscoring the urgent need for effective interventions. ZnO-NPs were successfully synthesized and characterized using UV-visible spectroscopy, FT-IR, XRD, and TEM, confirming their formation with an average size of 15.7 nm and reflecting their suitability for antimicrobial and biological applications. ZnO-NPs exhibited potent antibacterial activity, with a maximum inhibition zone of 24.4 ± 0.4 mm at 20 μg/disk, MIC values of 6.25–25 μg/mL, and MBC values of 12.5–50 μg/mL. Additionally, biofilm formation was inhibited by up to 92.1% at 250 μg/mL. Our mechanistic study confirmed that ZnO-NPs damage bacterial membranes and DNA, leading to the intracellular leakage of cell components that lead to bacterial cell lysis. The use of S. rebaudiana in ZnO-NP synthesis aligns with green chemistry principles, offering an eco-friendly alternative to conventional antibiotics and enhancing the bioactivity of ZnO-NPs, and may address the growing issue of antimicrobial resistance, thereby contributing to improved food safety and public health protection. Full article
(This article belongs to the Special Issue Metal Nanostructures in Biological Applications)
Show Figures

Figure 1

Back to TopTop