New Challenges in Antimicrobial Nanomaterials

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (20 February 2025) | Viewed by 729

Special Issue Editors


E-Mail Website
Guest Editor
Biomaterials Processing Laboratory, Department of Mechanical Engineering, University College London, Gower Street, London, UK
Interests: processing and forming of biomaterials and biostructures incorporating particles; bubbles; capsules and fibres at all scales

E-Mail Website
Guest Editor
School of Engineering and Technology, University of Hertfordshire, College Lane, Hatfield AL10 9AB, UK
Interests: antiviral and antimicrobial nanoparticles; biomedical applications; healthcare applications
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleague,

Antimicrobial nanomaterials are facing new challenges in biomedical and healthcare settings. These challenges span meeting regulatory hurdles, scalability in terms of cost, and sustainability. Also, more detailed research needs be intensified in some important areas such as the mechanism of action against bacteria and fungi; toxicities in vitro, in vivo, or ex vivo; biocompatibility; and environmental impact.

The current major concerns for nanomaterials in biomedical applications are the safety issues for human and animal uses. The balance between effective antimicrobial action and minimal toxicity to infection is crucial. Other issues include the potential environmental impact of nanomaterials, including their persistence and accumulation in ecosystems. This also includes understanding how they interact with various environmental components and their long-term effects.

Although antimicrobial nanomaterials are designed to reduce the likelihood of antimicrobial resistance (AMR), there is still a risk that microbes could develop resistance over time and research is needed to understand more details on their annihilation mechanisms of action and mitigate this risk in terms of optimising their formulation design, processing, and applications. This may cover the establishment of standardise regulatory frameworks for safe use such as guidelines for their production, usage, and disposal. Therefore, producing these materials on a large scale in a cost-effective manner remains a significant challenge. Moreover, innovations in manufacturing processes are urgently needed to make them commercially viable, which also has to follow current governmental guidelines on sustainability and Net Zero targets.

These challenges require multidisciplinary collaboration solutions to harness the full potential of antimicrobial nanomaterials while ensuring their sustainability, safety, and efficacy. Therefore, this Special Issue invites authors to submit their research for publication in the above key areas and beyond. 

Prof. Dr. Mohan Edirisinghe
Dr. Guogang Ren
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanomaterials
  • antimicrobial
  • antiviral
  • antibacterial
  • antifungal

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

22 pages, 3211 KiB  
Article
The Composition of the Dispersion Medium Determines the Antibacterial Properties of Copper (II) Oxide Nanoparticles Against Escherichia coli Bacteria
by Olga V. Zakharova, Alexander A. Gusev, Peter A. Baranchikov, Svetlana P. Chebotaryova, Svetlana S. Razlivalova, Elina Y. Koiava, Anna A. Kataranova, Gregory V. Grigoriev, Nataliya S. Strekalova and Konstantin V. Krutovsky
Nanomaterials 2025, 15(6), 469; https://doi.org/10.3390/nano15060469 - 20 Mar 2025
Viewed by 463
Abstract
Copper (II) oxide nanoparticles (CuO NPs) attract much attention as a promising antimicrobial agent. We studied the antibacterial properties of three types of CuO NPs against Escherichia coli bacteria: flake-shaped particles with a diameter of 50–200 nm and a thickness of 10–20 nm [...] Read more.
Copper (II) oxide nanoparticles (CuO NPs) attract much attention as a promising antimicrobial agent. We studied the antibacterial properties of three types of CuO NPs against Escherichia coli bacteria: flake-shaped particles with a diameter of 50–200 nm and a thickness of 10–20 nm (CuO-CD synthesized by chemical deposition), spherical particles with a size of 20–90 nm (CuO-EE obtained by electrical explosion), and rod-shaped particles with a length of 100–200 nm and a diameter of 30 × 70 nm (CuO-CS commercial sample). We tested how the shape, size, and concentration of the NPs, and composition of the dispersion medium affected the properties of the CuO NPs. We prepared dispersions based on distilled water, a 0.9% NaCl solution, and the LB broth by Lennox and used Triton X-100 and sodium dodecyl sulfate (SDS) as stabilizers. The concentration of NPs was 1–100 mg L−1. We showed that the dispersion medium composition and stabilizer type had the greatest influence on the antibacterial effects of CuO NPs. We observed the maximum antibacterial effect for all CuO NP types dispersed in water without a stabilizer, as well as in LB broth with the SDS stabilizer. The maximum inhibition of culture growth was observed under the influence of CuO-EE (by 30%) and in the LB broth with the SDS stabilizer (by 1.3–1.8 times depending on the type of particles). In the saline solution, the antibacterial effects were minimal; in some cases, the CuO NPs even promoted bacterial culture growth. SDS increased the antibacterial effects of NPs in broth and saline but decreased them in water. Finally, among the particle types, CuO-CS turned out to be the most bactericidal, which is probably due to their rod-shaped morphology and small diameter. At the same time, the concentration and aggregation effects of CuO NPs in the colloidal systems we studied did not have a linear action on their antibacterial properties. These results can be used in the development of antibacterial coatings and preparations based on CuO NPs to achieve their maximum efficiency, taking into account the expected conditions of their use. Full article
(This article belongs to the Special Issue New Challenges in Antimicrobial Nanomaterials)
Show Figures

Graphical abstract

Back to TopTop