Advances in Bioactive Nanoparticles on Wound Healing, Tissue Engineering, and Drug Delivery: 2nd Edition

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (20 March 2025) | Viewed by 2336

Special Issue Editors


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Guest Editor
Institute of Organic Synthesis and Photoreactivity (ISOF-CNR), Bologna, Italy
Interests: inorganic lamellar solids; hydrotalcites; hybrid materials; nanocomposites; biomaterials; silk fibroin extraction; purification and processing
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E-Mail Website
Guest Editor
Institute of Organic Synthesis and Photoreactivity (ISOF-CNR), Bologna, Italy
Interests: biopolymer processing; electrospinning; nanocomposites; keratin nanofibers and nanoparticles; drug delivery systems; wound healing system
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Institute of Organic Synthesis and Photoreactivity (ISOF-CNR), Rome, Italy
Interests: fluorescent dyes; photoactive compounds; biomaterials; biopolymers; drug delivery systems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Following the tremendous success of the first edition of the Special Issue “Advances in Bioactive Nanoparticles on Wound Healing, Tissue Engineering and Drug Delivery”, in which a total of five papers were published (https://www.mdpi.com/journal/nanomaterials/special_issues/Bioactive_Nano), a second edition is being launched.

In recent years, a lot of research has been directed towards the study of bioactive inorganic, organic, and/or hybrid nanoparticles in the biomedical field. These nanomaterials play an important role in drug delivery, imaging, diagnostics, wound healing, and tissue engineering applications. In this respect, different materials have been studied and investigated, such as iron oxide, gold, and silver nanoparticles; polymeric nanoparticles; lamellar solids; and nanocomposites. We invite authors to contribute original research or review articles covering the most recent progress and novel developments in the synthesis, design, use, and characterization of different nanoparticles and nanocomposites for drug delivery, tissue engineering, wound healing, and, more generally, biomedical technologies. This Special Issue will cover a broad range of subjects, ranging from nanoparticle synthesis to characterization and application. Welcomed study formats include full papers, communications, and reviews. Potential topics include, but are not limited to, the following:

  • Nanoparticle and nanocomposite development, synthesis, and fabrication for drug delivery, drug release, and tissue engineering;
  • Inorganic, organic, and hybrid nanoparticles;
  • Nanoparticle-based technologies for biomedical applications;
  • Characterization of nanoparticles and nanocomposites and the study of their biocompatibility/toxicity towards different cell lines.

We look forward to receiving your contributions.

Dr. Tamara Posati
Dr. Annalisa Aluigi
Dr. Giovanna Sotgiu
Guest Editors

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Keywords

  • nanoparticles
  • nanocomposites
  • biomedical applications
  • drug delivery
  • drug release
  • wound healing
  • tissue engineering

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Published Papers (2 papers)

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Research

20 pages, 8533 KiB  
Article
Designing and Fabrication of Nano-Hydroxyapatite and Curcumin-Loaded Chitosan/PVA Nanofibrous Mats for Potential Use as Wound Dressing Biomaterials
by Amira M. EL-Rafei, Giorgia Maurizii, Annalisa Aluigi, Giovanna Sotgiu, Marianna Barbalinardo and Tamara Posati
Nanomaterials 2025, 15(2), 82; https://doi.org/10.3390/nano15020082 - 7 Jan 2025
Cited by 1 | Viewed by 972
Abstract
Chitosan/polyvinyl alcohol nanofibrous mats loaded with nano-hydroxyapatite and/or curcumin are successfully fabricated by the electrospinning method for the first time. Nano-hydroxyapatite is prepared by the co-precipitation method. The XRD pattern of calcined powder at 700 °C for 2 h reveals the presence of [...] Read more.
Chitosan/polyvinyl alcohol nanofibrous mats loaded with nano-hydroxyapatite and/or curcumin are successfully fabricated by the electrospinning method for the first time. Nano-hydroxyapatite is prepared by the co-precipitation method. The XRD pattern of calcined powder at 700 °C for 2 h reveals the presence of hydroxyapatite as a sole phase. FT-IR confirms its purity. The morphology of the hydroxyapatite is studied by HR-TEM. Nano-hydroxyapatite and curcumin are added at 5 wt% with respect to the polymer weight. XRD, FE-SEM, FT-IR, and HR-TEM are used to characterize the fabricated nanofibrous mats. The results confirm the successful loading of nano-hydroxyapatite and curcumin within the fabricated mats. The in vitro antimicrobial results show that most of mats have significant antimicrobial effects against E. coli and S. aureus. The fabricated matd are biocompatible with fibroblasts and the presence of curcumin increases cell viability. Curcumin release from both CS/PVA/Cur and CS/PVA/HA/Cur nanofiber mats principally follows the Korsmeyer–Peppas and Peppas–Salhin models. Full article
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17 pages, 16304 KiB  
Article
Silver Nanoparticles and Simvastatin-Loaded PLGA-Coated Hydroxyapatite/Calcium Carbonate Scaffolds
by Morena Nocchetti, Chiara Piccotti, Michela Piccinini, Silvia Caponi, Maurizio Mattarelli, Donatella Pietrella, Alessandro Di Michele and Valeria Ambrogi
Nanomaterials 2024, 14(20), 1637; https://doi.org/10.3390/nano14201637 - 12 Oct 2024
Viewed by 1046
Abstract
The need to develop synthetic bone substitutes with structures, properties, and functions similar to bone and capable of preventing microbial infections is still an ongoing challenge. This research is focused on the preparation and characterization of three-dimensional porous scaffolds based on hydroxyapatite (HA)-functionalized [...] Read more.
The need to develop synthetic bone substitutes with structures, properties, and functions similar to bone and capable of preventing microbial infections is still an ongoing challenge. This research is focused on the preparation and characterization of three-dimensional porous scaffolds based on hydroxyapatite (HA)-functionalized calcium carbonate loaded with silver nanoparticles and simvastatin (SIMV). The scaffolds were prepared using the foam replica method, with a polyurethane (PU) sponge as a template, followed by successive polymer removal and sintering. The scaffolds were then coated with poly(lactic-co-glycolic) acid (PLGA) to improve mechanical properties and structural integrity, and loaded with silver nanoparticles and SIMV. The scaffolds were characterized by X-ray powder diffraction (XRD), field emission scanning electron microscopy (FE-SEM), ATR FT-IR, and silver and SIMV loading. Moreover, the samples were analyzed by Brillouin and Raman microscopy. Finally, in vitro bioactivity, SIMV and silver release, and antimicrobial activity against Staphylococcus aureus and Staphylococcus epidermidis were evaluated. From the Brillouin spectra, samples showed characteristics analogous to those of bone tissue. They exhibited new hydroxyapatite growth, as evidenced by SEM, and good antimicrobial activity against the tested bacteria. In conclusion, the obtained results demonstrate the potential of the scaffolds for application in bone repair. Full article
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