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Applications of Natural Products in Food

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: closed (1 August 2022) | Viewed by 2633

Special Issue Editors

Department of Clinical Pharmacy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Interests: food–drug interaction; natural product; drug development; pharmacology; drug metabolism; nutraceuticals
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Guest Editor
Department of Pharmaceutics, College of Pharmacy King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia
Interests: food–drug interaction; natural product; drug development; pharmacology; drug metabolism; nutraceuticals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Traditional and modern therapies use natural compounds as active ingredients. The use of natural compounds as starting points for drug development is common because of the structural variety they provide and the ease with which synthetic analogues can be created. It is common to classify natural products into main and secondary metabolites. The term “natural product” refers to any substance produced by a living organism. Chemicals or mixtures of compounds contained in these items have been shown to have favorable impacts on the matrix of which they are a part (i.e., foods, dietary supplements, or cosmetics). Organoleptic changes, a longer shelf life, and improved technological qualities are all examples of these positive consequences. Furthermore, food can also have a positive impact on the organism that eats it. Increased research in recent decades on the connection between nutrition and chronic illness incidence has shown the exceptional opportunities afforded by food to maintain and even improve health status. With the goal of keeping or improving health in mind it is possible to enhance foods with natural chemicals that have diverse biological activity in order to avoid food–medication interactions. Natural substances must be evaluated in terms of their potential impact on both the food matrix and the human body. Consequently, the goal for this Special Issue of is to publish papers focusing on the applications and evaluations of impacts and activities of natural products used in food in terms of safety and food health values. The processes underlying the effects produced by natural products will also be investigated in the papers submitted for consideration.

Prof. Dr. Ajaz Ahmad
Prof. Dr. Mohammad Raish
Guest Editors

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Keywords

  • bioactive and phenolic compounds
  • extraction and analysis of constituents in foods
  • structural characterization
  • stability
  • biotransformation of compounds in food
  • antioxidant properties
  • health benefits and implications
  • pharmacokinetics and pharmacodynamics
  • herb/food–drug interaction
  • analysis of compounds in biological systems

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Published Papers (1 paper)

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Research

19 pages, 24747 KiB  
Article
Z-Guggulsterone Is a Potential Lead Molecule of Dawa-ul-Kurkum against Hepatocellular Carcinoma
by Meenakshi Gupta, Shaikh Maryam Ghufran, Tasneem Kausar, Rafat Ali, Subhrajit Biswas, Shahid M. Nayeem, Romana Ishrat, Sher Ali, Ajaz Ahmad, Irfan A. Rather and Maryam Sarwat
Molecules 2022, 27(16), 5104; https://doi.org/10.3390/molecules27165104 - 11 Aug 2022
Cited by 6 | Viewed by 2301
Abstract
An ancient saffron-based polyherbal formulation, Dawa-ul-Kurkum (DuK), has been used to treat liver ailments and other diseases and was recently evaluated for its anticancer potential against hepatocellular carcinoma (HCC) by our research team. To gain further insight into the lead molecule of DuK, [...] Read more.
An ancient saffron-based polyherbal formulation, Dawa-ul-Kurkum (DuK), has been used to treat liver ailments and other diseases and was recently evaluated for its anticancer potential against hepatocellular carcinoma (HCC) by our research team. To gain further insight into the lead molecule of DuK, we selected ten active constituents belonging to its seven herbal constituents (crocin, crocetin, safranal, jatamansone, isovaleric acid, cinnamaldehyde, coumaric acid, citral, guggulsterone and dehydrocostus lactone). We docked them with 32 prominent proteins that play important roles in the development, progression and suppression of HCC and those involved in endoplasmic reticulum (ER) stress to identify the binding interactions between them. Three reference drugs for HCC (sorafenib, regorafenib, and nivolumab) were also examined for comparison. The in silico studies revealed that, out of the ten compounds, three of them—viz., Z-guggulsterone, dehydrocostus lactone and crocin—showed good binding efficiency with the HCC and ER stress proteins. Comparison of binding affinity with standard drugs was followed by preliminary in vitro screening of these selected compounds in human liver cancer cell lines. The results provided the basis for selecting Z-guggulsterone as the best-acting phytoconstituent amongst the 10 studied. Further validation of the binding efficiency of Z-guggulsterone was undertaking using molecular dynamics (MD) simulation studies. The effects of Z-guggulsterone on clone formation and cell cycle progression were also assessed. The anti-oxidant potential of Z-guggulsterone was analyzed through DPPH and FRAP assays. qRTPCR was utilized to check the results at the in vitro level. These results indicate that Z-guggulsterone should be considered as the main constituent of DuK instead of the crocin in saffron, as previously hypothesized. Full article
(This article belongs to the Special Issue Applications of Natural Products in Food)
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