Green Synthesis of Small Heterocyclic Molecules through Multicomponent Approaches

Dear Colleagues,

Developing sustainable synthetic methods for biologically important small heterocyclic target molecules with minimal environmental effects is stimulating. Over the years, new advances to the synthesis of heterocycles are a massive impact on synthetic organic chemistry. The multicomponent reactions (MCRs) generate small heterocycles or utilise them as starting precursors. MCRs simultaneously involve three or more components, developing in products that integrate the elements of all starting substrates in their frameworks. This integrative environment of MCRs is desirable when rapid growth in molecular diversity is preferred. Employing a combinatorial attempt, sets of components can be systematically distributed in arrays of reactions to produce iterations on familiar MCR-product derivatives. New multicomponent domino procedures replace the classical condensation procedures to synthesise heterocyclic compounds. Therefore, developing new approaches to heterocycle synthesis is of significant research interest for green and sustainable research. This topic is crucial for drug development; as a result, greener approaches to heterocyclic molecules are receiving growing attention from the scientific community.

In this perspective, the research topic “Green Synthesis of Small Heterocyclic Molecules through Multicomponent Approaches” Special Issue will be a collection of original research and review articles focusing on heterocyclic compounds synthesis according to green chemistry principles. It will accept some recent advances in heterocycles preparation that employ more sustainable synthetic protocols. The focal point is to build on efficient, sustainable methodologies aiming at high process performances utilising non-toxic/green and biodegradable materials.

Prof. Dr. Sreekantha B. Jonnalagadda
Dr. Nagaraju Kerru
Guest Editors

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• multicomponent reactions
• green/renewable-based solvents
• green principles
• one-pot synthesis
• bio-active compounds
• heterogeneous catalysis