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Special Issue "Chemogenomics in Drug Discovery"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: 31 January 2019

Special Issue Editor

Guest Editor
Dr. David Drewry

Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Website | E-Mail
Interests: chemogenomics; compound set design; kinase inhibitors; chemical probes; phenotypic screening; drug discovery; selectivity; open science

Special Issue Information

Dear Colleagues,

Chemogenomic sets are well-annotated collections of small molecules often used in disease relevant phenotypic screens. Chemogenomic set screening results suggest that the target(s) modulated by the active compounds are relevant to the measured phenotype and worthy of further exploration. Screening of these sets provides a useful bridge between phenotypic screening and target-based screening. The broad annotation of these sets offers great value, contributing data for model development that enables virtual screening exercises, and providing enhanced understanding of protein class selectivity challenges which leads to smart compound design.

The aim of this Special Issue is to highlight recent efforts in all aspects of “Chemogenomics in Drug Discovery”. We invite your submission describing the design of or use of chemogenomic sets. Contributions may also include the design, synthesis, and screening of protein family directed compounds. Computational model development and other uses of available chemogenomic set annotation data are also in scope for this issue. We welcome original articles, short communications, and review articles.

Dr. David Drewry
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • chemogenomics
  • phenotypic screening
  • annotated compound sets
  • compound set design
  • protein target class inhibitors
  • careful compound selection
  • repurposing

Published Papers

This special issue is now open for submission.
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