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Antimicrobial and Antibacterial Films for Tissue Regeneration

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: closed (30 July 2022) | Viewed by 2596

Special Issue Editor


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Guest Editor
Grupo de Investigación de Fotoquímica y Fotobiología, Facultad de Ciencias, Universidad del Atlántico, Carrera 30 Número 8-49, 081008 Puerto Colombia, Colombia
Interests: tissue engineering; acrylic cement for bone biomedical applications; chitosan–essential oil composites for food preservation; scaffolds for antimicrobial and tissue engineering applications; chitosan beads and hydrogels for adsorption contamination; valorization of food waste
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Special Issue Information

Dear Colleagues,

Composite and nanocomposite films, including biopolymers, have attracted worldwide attention thanks to their ability to support cell adhesion and growth factor liberation, and provide structural support to tissues and organs. Furthermore, depending on the nanofillers or composite design, antimicrobial properties can be introduced, of immense relevance for medicine. For example, chitosan and carbon nanomaterials are known strategies to add antimicrobial support without compromising the biocompatibility of the films.

This Special Issue, “Antimicrobial and tissue engineering applications,” aims to cover the latest developments regarding the synthesis, functionalization, characterization, and application of antimicrobial and biocompatible films in tissue engineering and wound dressing fields. It represents an excellent opportunity for researchers to present their latest work to address the fundamental aspects and applied research within this field. This Special Issue will also highlight new challenges in efficiently producing or designing film-specific applications.

Full articles, short communications, or review articles are welcome.

Dr. Carlos David Grande Tovar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Antimicrobial films
  • Antimicrobial composites
  • Nanocomposites 
  • Tissue engineering
  • Biocompatibility
  • Antifungal films
  • Antibacterial films
  • Antimicrobial surface coatings
  • Cell adhesion
  • Polymer composites
  • Wound dressing
  • Hydrogels
  • Regenerative medicine

Published Papers (1 paper)

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Research

25 pages, 8252 KiB  
Article
Biocompatibility Assessment of Polylactic Acid (PLA) and Nanobioglass (n-BG) Nanocomposites for Biomedical Applications
by Jorge Iván Castro, Carlos Humberto Valencia Llano, Diego López Tenorio, Marcela Saavedra, Paula Zapata, Diana Paola Navia-Porras, Johannes Delgado-Ospina, Manuel N. Chaur, José Hermínsul Mina Hernández and Carlos David Grande-Tovar
Molecules 2022, 27(11), 3640; https://doi.org/10.3390/molecules27113640 - 06 Jun 2022
Cited by 4 | Viewed by 2139
Abstract
Scaffolds based on biopolymers and nanomaterials with appropriate mechanical properties and high biocompatibility are desirable in tissue engineering. Therefore, polylactic acid (PLA) nanocomposites were prepared with ceramic nanobioglass (PLA/n-BGs) at 5 and 10 wt.%. Bioglass nanoparticles (n-BGs) were prepared using a sol–gel methodology [...] Read more.
Scaffolds based on biopolymers and nanomaterials with appropriate mechanical properties and high biocompatibility are desirable in tissue engineering. Therefore, polylactic acid (PLA) nanocomposites were prepared with ceramic nanobioglass (PLA/n-BGs) at 5 and 10 wt.%. Bioglass nanoparticles (n-BGs) were prepared using a sol–gel methodology with a size of ca. 24.87 ± 6.26 nm. In addition, they showed the ability to inhibit bacteria such as Escherichia coli (ATCC 11775), Vibrio parahaemolyticus (ATCC 17802), Staphylococcus aureus subsp. aureus (ATCC 55804), and Bacillus cereus (ATCC 13061) at concentrations of 20 w/v%. The analysis of the nanocomposite microstructures exhibited a heterogeneous sponge-like morphology. The mechanical properties showed that the addition of 5 wt.% n-BG increased the elastic modulus of PLA by ca. 91.3% (from 1.49 ± 0.44 to 2.85 ± 0.99 MPa) and influenced the resorption capacity, as shown by histological analyses in biomodels. The incorporation of n-BGs decreased the PLA crystallinity (from 7.1% to 4.98%) and increased the glass transition temperature (Tg) from 53 °C to 63 °C. In addition, the n-BGs increased the thermal stability due to the nanoparticle’s intercalation between the polymeric chains and the reduction in their movement. The histological implantation of the nanocomposites and the cell viability with HeLa cells higher than 80% demonstrated their biocompatibility character with a greater resorption capacity than PLA. These results show the potential of PLA/n-BGs nanocomposites for biomedical applications, especially for long healing processes such as bone tissue repair and avoiding microbial contamination. Full article
(This article belongs to the Special Issue Antimicrobial and Antibacterial Films for Tissue Regeneration)
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