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Special Issue "Synthesis and Bioactivity of Coumarin and Coumarin Derivatives"

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: 31 July 2020.

Special Issue Editor

Prof. Dr. Konstantinos E. Litinas
Website
Guest Editor
Aristotle University of Thessaloniki, Department of Chemistry, Thessaloniki, Greece
Interests: organic synthesis; natural products synthesis; coumarin derivatives; purine derivatives; modified N-homonucleosides; synthesis of compounds with possible biological activity; application of organometallic reagents in organic synthesis (olefin metathesis, cross-coupling reactions); synthesis under microwaves

Special Issue Information

Dear Colleagues,

Coumarin (2H-1-benzopyran-2-one) is wide spread as an essential core moiety in a variety of natural products occurring in plants, bacteria, and fungi. Coumarin is synthesized in nature through the shikimate biosynthetic pathway, and it is also metabolized to hydroxycoumarins. Coumarins present interesting biological properties, such as anticoagulant, antibiotic, anti-inflammatory, antioxidant, anti-HIV, anticancer, thermal photosensitizing, vasodilator, and estrogenic activity.

Especially, hydroxycoumarin derivatives are used as anticoagulant, antibiotic, or choleretic drugs. 7-Aminocoumarins are useful as biological sensors showing fluorescence activity. Fused furanocoumarin derivatives are used for treating psoriasis, and they also exhibit anti-inflammatory, antibacterial, antifungal, and cytochrome P-450 inhibitor properties. Fused pyranocoumarins present anti-HIV, anticancer, anti-inflammatory, antifungal activities, and they play an important role in the regulation of root growth in different plants. Fused pyrrolocoumarins possess cytotoxic, anti-HIV, anti-inflammatory, photobiological, and antiproliferative properties. Fused pyridocoumarins present anticholinergic, antidiabetic, antiallergic, antipsychotic, and antimicrobial activities.

Prof. Dr. Konstantinos E. Litinas
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Coumarin synthesis
  • Coumarin bioactivity
  • Coumarin derivatives
  • Hydroxycoumarins
  • Aminocoumarins
  • Fused coumarins
  • Furanocoumarins
  • Pyranocoumarins
  • Pyrrolocoumarins
  • Pyridocoumarins

Published Papers (1 paper)

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Review

Open AccessReview
Antagonists of Vitamin K—Popular Coumarin Drugs and New Synthetic and Natural Coumarin Derivatives
Molecules 2020, 25(6), 1465; https://doi.org/10.3390/molecules25061465 - 24 Mar 2020
Abstract
Many natural coumarins and their chemically synthesized analogs and derivatives exert diverse properties, such as anticancer, antioxidant, anti-inflammatory, or anticoagulant, with the latter being of the utmost importance. The widely used warfarin, acenocoumarol, and phenprocoumon exert anticoagulant properties by inhibiting the vitamin K [...] Read more.
Many natural coumarins and their chemically synthesized analogs and derivatives exert diverse properties, such as anticancer, antioxidant, anti-inflammatory, or anticoagulant, with the latter being of the utmost importance. The widely used warfarin, acenocoumarol, and phenprocoumon exert anticoagulant properties by inhibiting the vitamin K epoxide reductase complex. In this interdisciplinary review, we present biochemical principles of the coagulation processes and possible methods for their tuning based on the use of coumarins. We also summarize chemical methods of synthesis of coumarins and discuss structures and properties of those that have been used for a long time, as well as newly synthesized compounds. Brief information on the clinical use of coumarins and other anticoagulant drugs is given, including the severe effects of overdosing and methods for reversing their action. Full article
(This article belongs to the Special Issue Synthesis and Bioactivity of Coumarin and Coumarin Derivatives)
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