Special Issue "Synthesis and Bioactivity of Coumarin and Coumarin Derivatives"
A special issue of Molecules (ISSN 1420-3049).
Deadline for manuscript submissions: 31 July 2020.
Interests: organic synthesis; natural products synthesis; coumarin derivatives; purine derivatives; modified N-homonucleosides; synthesis of compounds with possible biological activity; application of organometallic reagents in organic synthesis (olefin metathesis, cross-coupling reactions); synthesis under microwaves
Coumarin (2H-1-benzopyran-2-one) is wide spread as an essential core moiety in a variety of natural products occurring in plants, bacteria, and fungi. Coumarin is synthesized in nature through the shikimate biosynthetic pathway, and it is also metabolized to hydroxycoumarins. Coumarins present interesting biological properties, such as anticoagulant, antibiotic, anti-inflammatory, antioxidant, anti-HIV, anticancer, thermal photosensitizing, vasodilator, and estrogenic activity.
Especially, hydroxycoumarin derivatives are used as anticoagulant, antibiotic, or choleretic drugs. 7-Aminocoumarins are useful as biological sensors showing fluorescence activity. Fused furanocoumarin derivatives are used for treating psoriasis, and they also exhibit anti-inflammatory, antibacterial, antifungal, and cytochrome P-450 inhibitor properties. Fused pyranocoumarins present anti-HIV, anticancer, anti-inflammatory, antifungal activities, and they play an important role in the regulation of root growth in different plants. Fused pyrrolocoumarins possess cytotoxic, anti-HIV, anti-inflammatory, photobiological, and antiproliferative properties. Fused pyridocoumarins present anticholinergic, antidiabetic, antiallergic, antipsychotic, and antimicrobial activities.
Prof. Dr. Konstantinos E. Litinas
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- Coumarin synthesis
- Coumarin bioactivity
- Coumarin derivatives
- Fused coumarins