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New Mass Spectrometry-Based Approaches to Illuminate Glycosylation

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Chemical Biology".

Deadline for manuscript submissions: closed (15 August 2022) | Viewed by 940

Special Issue Editors

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Guest Editor
School of Medicine, University of California, San Francisco, CA, USA
Interests: hydrogen/deuterium exchange mass spectrometry; native mass spectrometry; proteomics

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Guest Editor
Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA, USA
Interests: proteomics; glycoproteomics; biomarkers; extracellular vesicles

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Guest Editor
Department of Medicinal Chemistry, University of Washington, Seattle, WA, USA
Interests: tandem mass spectrometry; DDA; O-linked Glycosylation; glycomics and glycoproteomics; HDX; Ion mobility; fragmentation mechanisms; computational chemistry

Special Issue Information

Dear Colleagues,

Glycosylation is one of the most prevalent and complicated forms of post-translational modification, and is implicated in many biological processes and diseases. Glycans are one of the four key biologically relevant molecules that are involved in a plethora of biological functions, including how our bodies fight and recognize viruses and how proteins move within our body, with significant attention paid to their influence on the efficacy of therapeutics. Moreover, the recent outbreak of COVID-19 has brought to the fore the importance of the study of glycosylation. Considering the biological importance of glycans, techniques for the accurate structural analysis of glycosylation on a broad scale are essential in the biopharmaceutical industry and beyond. However, the accurate characterization of glycans is hindered by the lack of high-throughput, high-resolution, and robust analytical techniques in the field of glycomics. Unlike the fields of genomics and proteomics, research in glycoscience has lagged because of the complexity of the glycans and the lack of automated high-throughput workflows. Genomics and proteomics only present a part of the understanding needed to explain important questions in biology, human health, and medicine. Though mass spectrometry is the go-to tool for studying glycosylation, some areas, such as O-linked glycosylation, remain challenging to study. The massive structural heterogeneity of glycans, along with the lack of an enzyme for deglycosylating O-linked glycans, has hindered their characterization. Thus, it is crucial to explore mass spectrometry-based approaches for glycan profiling, and to develop high-throughput screening methods, cost-effective enzymes for the deglycosylation of O-linked glycans, analytical methods to identify glycan biomarkers, and glyco-therapeutics that can be utilized by academia and industry alike.

In this context, this Special Issue, entitled “New Mass Spectrometry-based Approaches to Illuminate Glycosylation”, aims to gather new insights, studies, and innovative mass spectrometry-based methods and technologies for glycan analysis, glycan structural analysis, biomarker discovery from both simple (e.g., purified proteins, peptides, antibodies) and complex starting materials (e.g., red blood cells, serum, plasma), and data acquisition and analysis to mitigate gaps and bottlenecks in biomedical research.

Dr. Monita Muralidharan
Dr. Mayank Saraswat
Dr. Abhigya Mookherjee
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • glycoproteomics
  • glycomics
  • LC-MS/MS
  • biomarker discovery
  • glycans in diseases (Alzheimer‘s, neurodegeneration
  • cancer
  • immunology
  • tumor evasion
  • inflammation
  • liquid biopsy
  • glycoproteomics in health and disease
  • N- and O-glycans
  • lectin-affinity chromatography
  • glycoprotein enrichment
  • computational methods
  • data analysis/visualization

Published Papers

There is no accepted submissions to this special issue at this moment.
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