Redox-Active Molecules as Key Players for Inflammatory Diseases
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 507
Special Issue Editor
Interests: chemical biology; medicinal chemistry; antioxidant activity; redox process; antioxidant; lipid peroxidation
Special Issue Information
Dear Colleagues,
Most of the events occurring in biological systems in both plants and humans’ lives involve redox processes as molecular interactions are conducted by redox and/or acid–base actions in buffered media. Oxidation–reduction (redox) reactions are central to the existence of life. Several decades ago, the notion of oxidative stress emerged and was considered as a key player either in triggering biochemical disruption or in lesser degree for maintaining cellular homeostasis. As a result, mitochondrial dysfunction appears, leading to various diseases. Numerous studies have been reported showing a growing interest in inflammation, which is central in the development of several diseases including atherosclerosis, diabetes and cancer.
To tackle those diseases, there is an urgent need for new scaffold-based compounds designed to modulate enzyme activity, inhibiting bacteria growth and targeting mitochondria. Therefore, numerous chemical families have been developed both on quantitative structure–activity relationship (QSAR) and predictive studies such as computer assistance with pharmacokinetics. Macromolecules, nanoparticles and small compounds, depending on the disease, are good candidates. Also, several types of natural molecules have been isolated to achieve similar goals, i.e., tackling either bacteria involved in malaria or targeting sickle cells disease as well as mitochondrial dysfunction.
Furthermore, alkaline aqueous solutions, in addition to redox active natural compounds or their structural derivatives, can also be potent redox cyclers in microorganisms that participate in the modulation of pathogen growth by disrupting cellular redox homeostasis or the function of redox-sensitive cellular components.
This Special Issue aims to bring together researchers from various chemical specialties (pure synthesis, electrochemistry and medicinal chemistry, including pharmacognosy) to take part into the discovery of new redox drugs able to tackle diseases involving oxidative processes. A better understanding of the molecular and cellular basis of redox biology will help to achieve this goal with novel redox medicine approaches.
Dr. Ange Mouithys-Mickalad
Guest Editor
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Keywords
- redox-active Molecules
- oxidative stress
- inflammatory diseases
- QSAR
- computer-aided drug design
- redox active natural compounds
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