New Insights into Kinase Inhibitors II
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".
Deadline for manuscript submissions: closed (31 March 2025) | Viewed by 3852
Special Issue Editor
2. Dipartimento Salute della Donna e del Bambino, Università degli Studi di Padova, Padua, Italy
Interests: anticancer compounds; chemotherapy resistance; kinase inhibitors; antimitotic compounds; cancer pharmacology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This issue is a continuation of the previous successful Special Issue “New Insights into Kinase Inhibitors”.
In the last 30 years, kinases have been widely studied as drug targets to inhibit proliferation and angiogenesis in cancer therapy. Kinase inhibitors now represent one of the major classes of chemotherapeutics, with 52 kinase inhibitors having been approved as anticancer agents.
To date, 538 kinases are found to be active in the human body, where they are responsible for the phosphorylation of up to one-third of the proteome in controlling migration, survival, proliferation, and other processes via phosphorylation cascades. Moreover, aberrant kinase activity has been described to have an important role not only in cancer but also in inflammatory, degenerative, immunological, metabolic, and cardiovascular diseases.
Although their druggability and clinical safety profile make kinases attractive targets, the majority of kinases are still unexplored, and the field of kinase inhibitors is still growing.
This Special Issue will highlight new insights into the discovery of new kinase inhibitors, from the investigation of new targets to the identification of novel small molecules. Contributions to this issue, both in the form of original articles or reviews, may focus on powerful strategies and technological advances in the synthesis of more efficient and selective compounds, new strategies to overcome kinase inhibitors resistance, and improvements regarding the use of kinase inhibitors in oncology and other pathologies, in which therapeutic combinations with less toxic and off-target effects are considered.
Dr. Roberta Bortolozzi
Guest Editor
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Keywords
- kinase inhibitors
- kinase inhibitors chemistry
- therapy resistance
- combination therapy
- antitumoral activity
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Related Special Issues
- New Insights into Kinase Inhibitors II in Molecules (2 articles)
- New Insights into Kinase Inhibitors II in Molecules (2 articles)
