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Special Issue "New Trends in Functionalized Cyclodextrins"

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editor

Prof. Dr. Graziella Vecchio
E-Mail Website
Guest Editor
Università degli Studi di Catania, Catania, Italy
Interests: cyclodextrin derivatives; cyclodextrin-based nanoparticles; glycoconjugates; coordination compounds; bioinorganic chemistry
Special Issues and Collections in MDPI journals

Special Issue Information

Dear Colleagues,

Cyclodextrins are known in particular for their ability to form inclusion complexes with various molecules, and this feature forms the basis of their application in the chromatography, catalysis, pharmacy, cosmetics, agro-food, and textile industries.

The chemical modification of cyclodextrins has increased interest in these molecules and provides an attractive approach for building multifunctional systems. Many functionalized cyclodextrins have been synthesized with the aim of tuning the features of the cavity and to add new unique properties to the saccharide unit. A variety of moieties, such as drugs, peptides, metal chelators, macrocycles, and others, have been linked to cyclodextrins with applications in supramolecular, pharmaceutical, and material chemistry, biomimicry, and separation sciences.

More recently, interest in these molecules has extended to the synthesis of cyclodextrin-based nanosystems. Thus, a variety of organic and hybrid nanoparticles have been studied, and among them, some prodrug nanoparticles have been approved for phase III clinical trials as nanotherapeutics for treating cancer.

This Special Issue welcomes submissions of research communications, papers, and reviews with the aim of describing the multiple aspects and applications of functionalized cyclodextrins and cyclodextrin-based nanosystems.

Prof. Dr. Graziella Vecchio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Cyclodextrins 
  • Biomimetics 
  • Drug carriers 
  • Nanoparticles 
  • Prodrugs 
  • Synthesis of cyclodextrin derivatives 
  • Nanotherapeutics

Published Papers

This special issue is now open for submission, see below for planned papers.

Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Toward a Greener World – Cyclodextrin Derivatization by Mechanochemistry
Authors: Laszlo Jicsinszky, Giancarlo Cravotto
Affiliation: University of Turn, DSTF, Turin, Italy
Abstract: Cyclodextrin (CD) derivatives are a challenge, mainly due to solubility problems. In many cases, the synthesis of CD derivatives requires high-boiling solvents, whereas the product isolation from the aqueous methods often requires energy-intensive processes. In many cases, the solubility of both the starting material and the product in the same solvent differs significantly. The sweetest point of mechanochemistry is the reduced demand or complete elimination of solvents from the synthesis. The lack of solvents can make syntheses more economical and greener, but due to limited molecular movements, it allows the preparation of CD derivatives that are difficult to produce under solvent reaction conditions. A mechanochemical reaction generally has a higher reagent utilization rate. When the reaction yields a good guest co-product, solvent-free conditions can be slower than in solution conditions. Solventless reaction conditions can be well utilized in the synthesis of regioselective thioalkylated derivatives, as well as insoluble cyclodextrin polymers and nanosponges. In the case of thiolated CD derivatives, the absence of solvents results in significant suppression of the thiol group oxidation, too. The insoluble polymer synthesis is also more efficient using the same molar ratio of the reagents as the solution reaction. Not only the hydrolysis of the multifunctional reagents or their side reactions with the reaction-components are restricted, but the spatial proximity of the macrocycle also reduces the length of spacers formed from the crosslinking reagent. The structure of insoluble polymers of the mechanochemical reactions generally is more compact, with fewer and shorter hydrophilic arms than the products of the solution reactions.

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