Synthesis, Modification and Biomedical Potential of Peptides and Peptoids
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Bioorganic Chemistry".
Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 230
Special Issue Editor
Interests: antimicrobial peptides; immunoregulatory peptides; self-aggregation; mechanism of action; clinical applications
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Since the research and development of peptide compounds, they have been widely used in medicine, health care, food, cosmetics, biological materials and other fields. Among these, the medical field is the most promising market for peptide compounds. Compared with traditional chemical drugs, peptide compounds have the advantages of high biological activity, low toxicity, strong specificity, a good affinity with receptors and rarely accumulate in the body. In addition, they also have the various biological functions of antibacterial, antiviral and immune improvement. Thus, peptide compounds have a wide range of application prospects in the medical field, and have become the key direction of new drug research and development both at home and abroad.
At present, common peptide drugs are mainly obtained via three methods: animal tissue extraction, chemical synthesis and gene expression recombination. However, most peptides obtained through these pathways often have the problems such as metabolic instability, short half-life and low bioavailability. In order to overcome these obstacles and extend activity, some strategies such as amino acid substitution or cyclization, PEG modification, and the fusion of long-acting fragments are used to modify the molecular skeleton of parent peptides to improve their bioavailability. Additionally, synthetic peptoids also possess better medical potential. The side chain groups in the peptoids are attached to the nitrogen atoms in the main chain, giving the R group greater selectivity. Meanwhile, the peptoids are completely replaced by amide bonds during the synthesis process, yielding better protease hydrolysis resistance and water solubility for peptoids than the originals . Therefore, the modification of peptide compounds or the synthesis of peptoids are essential to promote the applications of peptide/peptoid drugs in the field of medicine.
The purpose of this research is to elucidate the synthesis and optimization strategies of peptide/peptoid drugs, provide a theoretical basis for the development of new peptide/peptoid drugs, and elaborate the antibacterial mechanism of peptide/peptoid drugs and their biomedical applications.
Dr. Jiajun Wang
Guest Editor
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Keywords
- peptides
- peptoids
- antimicrobial mechanisms
- peptide synthesis
- peptide modification
- medical applications
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