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Beyond Convention: Novel Sources, Strategies, and Technologies for Researching Fungal Bioactives

A special issue of Molecules (ISSN 1420-3049).

Deadline for manuscript submissions: 31 January 2026 | Viewed by 31

Special Issue Editors


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Guest Editor
Division of Life Science, Center for Chinese Medicine, The Hong Kong University of Science and Technology, Hong Kong, China
Interests: herbal standardization; herbal synergy; neurobiology
Special Issues, Collections and Topics in MDPI journals
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China
Interests: lichen taxonomy; species diversity; phylogeny and biogeography; tolerance of lichens; speciation; diversity survey; lichenized fungi
Special Issues, Collections and Topics in MDPI journals

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Guest Editor Assistant
Division of Life Science, Center for Chinese Medicine R&D, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China
Interests: molecular systematics; Chinese herbal medicine; cell biology

Special Issue Information

Dear Colleagues,

Fungi represent a vast reservoir of bioactive compounds with unparalleled structural diversity and therapeutic potential, yet they remain underexplored using conventional experimental approaches, which are constrained by cultivability limits, redundant sampling, and technological barriers. This Special Issue, “Beyond Convention: Novel Sources, Strategies, and Technologies for Researching Fungal Bioactives”, seeks to overcome these boundaries by spotlighting cutting-edge methodologies that are revolutionizing the field.

We welcome contributions that harness unconventional fungal sources—extremophiles, endophytes, lichen symbionts, and unculturable taxa—via metagenomics, alongside transformative technologies such as AI/ML-driven metabolite prediction, CRISPR-based pathway engineering, integrated omics (genome-mining, metabolomics), and advanced analytical platforms (NMR crystallography, IM-MS, microED). Studies may address novel compound discovery, biosynthesis elucidation, heterologous expression, or bioactivity-guided structure optimization.

By transcending traditional paradigms, this Special Issue aims to usher in a new era of fungal biodiscovery: one where synthetic biology, computational tools, and culture innovation converge to unlock bioactive “dark matter”. We welcome original research, reviews, and perspectives that bridge laboratory breakthroughs with real-world applications of fungi in medicine, agriculture, and industry.

Prof. Dr. Karl Wah-Keung Tsim
Dr. Xinyu Wang
Guest Editors

Dr. Meixia Yang
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fungal bioactives
  • genome mining
  • metagenomics
  • synthetic biology
  • AI-driven discovery
  • structure elucidation
  • extremophilic fungi
  • drug discovery pipelines

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Published Papers

This special issue is now open for submission.
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