Aptamer-Based Sensing Technology for Biomarker Analysis
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Analytical Chemistry".
Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 492
Special Issue Editors
Interests: electrochemical biosensor; aptamer; in-vivo monitoring; complex matrix
Interests: biosensors; lateral flow assays; electrochemical sensors; nanomaterials; diagnostics
Special Issue Information
Dear Colleagues,
Rapid progress in the analysis of disease-related biomarkers has led to a steadily increasing demand and unmet need for high-performance sensor technologies. Implementation of aptamer technologies coupled with electrochemical, optical, or many other techniques may provide an effective means toward the goal of rapid, sensitive detection of clinically relevant biomarkers. Aptamers, also known as “artificial antibodies”, are short single-stranded DNA/RNA oligonucleotides, or peptides that can be selected from synthetic libraries using a convenient in vitro selection approach, for example, systematic evolution of ligands by exponential enrichment (SELEX). This convenient selection approach, in retrospect, enables aptamers to bind a wide variety of target analytes, including small molecules, proteins and even cells, etc. Correspondingly, aptamer-based sensor technology is modular in a “plug-and-play” fashion, meaning that a general platform can be fabricated for the analysis of a broad range of targets, simply by replacing one aptamer by another. Complementary strategies (such as enzyme or nanomaterial amplifications ) can be employed into such technology to rationally tune affinity (ranging from micro- to picomolar level) and specificity.
This Special Issue on this topic will summarize advances and cutting-edge research work on aptamer-based technology for the analysis of biomarkers. We warmly welcome and look forward to your submission.
Prof. Dr. Hui Li
Dr. Claudio Parolo
Dr. Songjie Chen
Guest Editors
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Keywords
- aptamer-based technology
- sensor
- biomarker
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