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Applications of Bioactive Ingredients in Grape By-products
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Applications of Bioactive Ingredients in Grape By-products

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Food Chemistry".

Deadline for manuscript submissions: closed (31 March 2026) | Viewed by 1752

Special Issue Editors

Prof. Dr. Tzonka Ivanova Godjevargova

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Guest Editor
Department Biotechnology, Scientific Research Institute, Burgas State University “Prof. Dr. Assen Zlatarov”, 8010 Burgas, Bulgaria
Interests: plan extract; grapeseeds; grape skins; grape pomace; bioactive components; HPLC analysis; antilipid effect; antimicrobial effect; antioxidant effect; antidiabetic effect; nutritional value; application; supplement; food additive
Special Issues, Collections and Topics in MDPI journals
Dr. Yavor Lukanov Ivanov

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Guest Editor
Department Biotechnology, Burgas State University “Prof. Dr. Assen Zlatarov”, 8010 Burgas, Bulgaria
Interests: plan extracts; grape seeds; skins; pomace; preparation of extracts; bioactive components; application; food industry; cosmetic; medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Interest in natural bioactive compounds and their application is constantly increasing due to their valuable biological properties. The production of bioactive substances from agricultural by-products such as seeds, skins, and pomace is very promising since using by-products from winemaking means that the production cycle is completely closed and the ecological balance is not disturbed. Grape seeds, skins, and pomace are significant sources of phenolic compounds, including flavonoids, phenolic acids, procyanidins, anthocyanins, and stilbenes, which are associated with various health benefits, such as antioxidant, anti-inflammatory, antilipid, and antimicrobial activities. 

This Special Issue aims to present the biological effect of bioactive compounds in grape seeds, skins, and pomace and their application in the medicine, cosmetic, pharmacy, and food industries. Original scientific manuscripts or review manuscripts are welcome to focus on, but are not limited to, the following topics:

1. Bioactive compounds in grape by-products (seeds, skins, and pomace): Preparation of extract from grape seeds, skins, and pomace; preparation of an enriched extract with some strong antioxidant compounds—procyanidins, catechins, resveratrol, etc.; polyphenolic content; identification of individual bioactive compounds; nutritional value of extracts. 

2. Antioxidant, antilipid, anti-inflammatory, antidiabetic, anti-obesity, anticancer, and antimicrobial activities of bioactive compounds in grape by-products and mechanism of their action. Relationship between the chemical structure of the compounds and their biological activity. 

3. Application of bioactive compounds from grape by-products in the medicine, cosmetic, pharmacy, and food industries. 

We look forward to receiving your original contributions to this Special Issue that will enrich the knowledge in the field of the application of valuable bioactive compounds from grape seeds, skins, and pomace.

Prof. Dr. Tzonka Ivanova Godjevargova
Dr. Yavor Lukanov Ivanov
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioactive compounds
  • grape seeds, skins, and pomace
  • biological activity
  • application
  • medicine
  • cosmetics
  • pharmacy
  • food industry

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Published Papers (2 papers)

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20 pages, 1112 KB  
Article
Chemical Composition, Antioxidant and Immunomodulatory Properties of Syrah Grape Seed Extract
by Yavor Ivanov, Zlatina Chengolova, Kalina Tumangelova-Yuzeir, Adelina Yordanova, Ekaterina Ivanova-Todorova, Milena Nikolova-Vlahova and Tzonka Godjevargova
Molecules 2026, 31(4), 583; https://doi.org/10.3390/molecules31040583 - 7 Feb 2026
Cited by 1 | Viewed by 476
Abstract
The aim of this study was to obtain and characterize grape seed extract and to demonstrate its potential immunomodulatory properties in the autoimmune disease systemic lupus erythematosus (SLE). A Syrah grape seed extract was obtained using 70% aqueous ethanol, magnetic stirrer, 3 h. [...] Read more.
The aim of this study was to obtain and characterize grape seed extract and to demonstrate its potential immunomodulatory properties in the autoimmune disease systemic lupus erythematosus (SLE). A Syrah grape seed extract was obtained using 70% aqueous ethanol, magnetic stirrer, 3 h. The obtained extracts were concentrated by vacuum evaporation and dryer at 40 °C. The total phenolic content (TPC), the total amount of flavonoids (TF) and procyanidins (PC), and the antioxidant (AO) capacity of the extract were determined by spectrophotometric methods. The individual composition of the extract was demonstrated by the high-performance liquid chromatography (HPLC) method. The effect of grape seed extract (GSE) on peripheral blood mononuclear cells (PBMC) from healthy donors and patients with SLE was studied to compare Th1 and Th2 subsets and their expression of key activation markers—CD25 and HLA-DR. PBMC were cultured in the presence or absence of GSE, and the effects on Th1 and Th2 cells were analyzed by flow cytometry. GSE treatment increased the proportion of Th1 cells in both healthy individuals and SLE patients. In addition, a significant upregulation of the late activation marker HLA-DR was observed on Th1 cells obtained from patients with systemic lupus erythematosus (SLE). No significant effects were found on Th2 cell populations. These findings indicate that GSE can stimulate Th1-mediated immune responses in SLE, proving its potential immunomodulatory properties beyond its known antioxidant effects. Full article
(This article belongs to the Special Issue Applications of Bioactive Ingredients in Grape By-products)
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18 pages, 1112 KB  
Article
Upcycling of Whole Pisco Grape Pomace: Influence of Emerging Extractions on Antioxidant Potential and Functional Quality of the Lipophilic Fractions
by Issis Quispe-Fuentes, Fátima Rodríguez-Ramos, Jacqueline Poblete, Iván Leyton-Valle and Elsa Uribe
Molecules 2025, 30(18), 3776; https://doi.org/10.3390/molecules30183776 - 17 Sep 2025
Viewed by 929
Abstract
This work aimed to promote an integrated valorization approach for recovering lipophilic fractions from whole pisco grape pomace using emerging extraction technologies such as Randall (40 °C, 360 min) and Pressurized Liquid Extraction (PLE: 60 °C, 10 min) to characterize lipid-soluble biocompounds and [...] Read more.
This work aimed to promote an integrated valorization approach for recovering lipophilic fractions from whole pisco grape pomace using emerging extraction technologies such as Randall (40 °C, 360 min) and Pressurized Liquid Extraction (PLE: 60 °C, 10 min) to characterize lipid-soluble biocompounds and evaluate their functional quality and antioxidant potential. PLE achieved maximum extraction yields (11–15%). Extraction techniques did not significantly alter fatty acid profiles, with C18:2n6c linoleic acid being most abundant (65–69%), followed by C18:1n9c oleic acid (17–21%), while C20:1 eicosanoid acid was least prevalent (1–2%). The fatty acid profile enabled functional potential evaluation through atherogenicity, thrombogenicity, and hypocholesterolemic/ hypercholesterolemic ratios, showing values comparable to other lipid sources. α-Tocopherol content was significantly influenced by extraction techniques (87–645 μg/g), while polyphenol content showed no significant differences between methods (0.6–0.8 mg GAE/g extract). Randall demonstrated higher DPPH radical scavenging capacity (25–30%), while PLE presented higher ORAC values (68–120 μmolTE/g extract). This represents the first characterization of lipophilic fractions from this pomace type, highlighting how emerging extraction techniques affect recovery of high-quality, antioxidant-rich fractions. Results suggest their potential as functional biocompound sources and candidates for various applications, contributing to grape waste valorization strategies. Full article
(This article belongs to the Special Issue Applications of Bioactive Ingredients in Grape By-products)
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