Recent Advances of Anti-Infective Activity Compounds
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 30 June 2026 | Viewed by 2
Special Issue Editors
Interests: drug development for neglected tropical diseases; anti-inflammatory drug discovery; cancer therapeutics; medicinal chemistry
Interests: new drugs; drug design; drug discovery; infectious disease; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue, “Recent Advances of Anti-Infective Activity Compounds”, compiles high-level contributions centered on the chemical innovation, molecular optimization, and mechanistic characterization of compounds with activity against a broad spectrum of infectious agents. Emphasis is placed on advances in synthetic methodologies, molecular design strategies, and structural refinement aimed at enhancing potency, selectivity, physicochemical balance, and translational relevance. This edition highlights progress in the development of diverse scaffolds, including non-classical chemotypes, heterocyclic frameworks, hybrid structures, bioisosteric derivatives, metal-based entities, and prodrug systems activated by pathogen-specific biochemical transformations. Contributions applying integrated medicinal chemistry approaches, such as structure-guided optimization, ligand-based modeling, conformational control, and advanced computational workflows, are particularly valued. Studies employing state-of-the-art analytical, biophysical, and in vitro/in vivo methodologies to elucidate interaction profiles and stability, permeability, ADME characteristics, and PK/PD behavior further enrich this collection. Altogether, this Special Issue reflects the current landscape of anti-infective compound development and delineates emerging molecular strategies to address global challenges associated with infectious diseases and drug resistance.
Dr. Cauê Benito Scarim
Dr. Jean Leandro Dos Santos
Guest Editors
Manuscript Submission Information
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Keywords
- anti-infective agents
- medicinal chemistry
- antimicrobial resistance
- rational drug design
- structure–activity relationship (SAR)
- ligand- and structure-based optimization
- heterocyclic compounds
- prodrugs
- metal-based molecules
- bioisosteric modification
- hybrid molecules
- synthetic methodologies
- ADME profiling
- PK/PD parameters
- computational modeling
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