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Exploring the Antioxidant Activity of Natural Extracts: New Findings and Potential Food- and Non-Food-Related Applications

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Natural Products Chemistry".

Deadline for manuscript submissions: 26 March 2026 | Viewed by 976

Special Issue Editor


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Guest Editor
Department of Natural Sciences, University of Maryland Eastern Shore, MD 21853, USA
Interests: phytochemistry; materials science; applications in agriculture and food; antifouling; resin extraction
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Plants have long been recognized for their medicinal properties, with antioxidants playing a crucial role in protecting cells from oxidative stress and related diseases, acting as radical scavengers. Antioxidants, particularly those derived from plant extracts, have gained significant attention due to their potential to mitigate these harmful effects and promote overall health. However, over the last decade, potential antioxidant sources have expanded, including algae, shells, milk, fish, fungi, and more.

Recent scientific advancements have focused on identifying and utilizing plant-derived antioxidants to enhance health and develop novel therapeutic applications. Studies have demonstrated that bioactive compounds such as polyphenols, flavonoids, and carotenoids found in plant extracts exhibit strong antioxidant properties, making them valuable candidates for pharmaceutical, nutraceutical, and food preservation applications. The exploration of antioxidant activity in plant extracts offers a promising avenue for understanding their potential benefits in disease prevention and sustainable healthcare solutions. However, many of their potential applications lie outside of the pharmaceutical and biomedical fields, such as food preservation, cosmetics, packaging, antifouling protection, etc.

The Special Issue "Exploring the Antioxidant Activity of Natural Extracts: New Findings and Potential Food- and Non-Food-Related Applications" aims to advance the understanding of natural antioxidants derived from plant, microbial, and other biological sources. This issue will focus on identifying novel antioxidant compounds, optimizing extraction techniques, and evaluating their effectiveness in various applications. By highlighting both food-related and non-food-related uses, the issue seeks to bridge the gap between fundamental research and practical applications in industries such as pharmaceuticals, cosmetics, agriculture, and materials science. It presents the collection of the most recent findings in plants with extreme antioxidant content, also known as superfruits, best growth management practices correlated with the antioxidant yield from such fruits, innovating extraction and processing techniques and industrial technologies, nanotechnology polymeric and antifouling coatings with antioxidants incorporated, their use in environmental protection, and many other topics.

Molecules is an international, peer-reviewed journal dedicated to chemistry and its interdisciplinary applications. Its scope includes organic chemistry, medicinal chemistry, natural products chemistry, materials science, and analytical chemistry. This Special Issue aligns with the journal’s scope by emphasizing the chemical characterization, bioactivity, and technological applications of antioxidant molecules. Given the journal’s commitment to publishing cutting-edge research, this issue will contribute valuable insights into the molecular mechanisms and industrial potential of natural antioxidants. 

By bridging fundamental research with applied science, this issue aims to accelerate the development of sustainable solutions utilizing natural antioxidants, fostering advancements across multiple disciplines.

As a part of this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Plant sources of antioxidants and best growth practices correlated with antioxidant yield
  • Superfruits and specialty crops for antioxidant extraction
  • Extraction and processing methods that preserve antioxidants
  • Proof of health benefits brought about by antioxidants. Examples: anti-obesity, anti-inflammation, anti-cancer, anti-viral activities, etc.
  • Food processing to create products rich in antioxidants
  • Non-food-related applications of antioxidants. Examples: antifouling protection, immune boosters for other plants, and conductive elements of batteries
  • New biomedical applications of antioxidants

I look forward to receiving your contributions.

Dr. Victoria V. Volkis
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural antioxidants
  • superfruits
  • specialty crops
  • polyphenols
  • flavonoids
  • tannins
  • anthocyanins
  • carotenoids
  • vitamins
  • phytochemistry
  • extraction techniques
  • processing
  • functional food
  • sustainable technology
  • technical applications
  • antifouling
  • obesity
  • inflammation
  • diabetes
  • cosmetics
  • pharmaceuticals
  • environmental protection
  • material science
  • radical scavenging
  • nutraceuticals

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Published Papers (1 paper)

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Research

25 pages, 3037 KB  
Article
Changes in Resveratrol Containing Phytosterol Liposomes During Model Heating
by Joanna Igielska-Kalwat, Magdalena Rudzińska, Anna Grygier, Dominik Kmiecik, Katarzyna Cieślik-Boczula and Jolanta Tomaszewska-Gras
Molecules 2025, 30(23), 4645; https://doi.org/10.3390/molecules30234645 - 3 Dec 2025
Viewed by 242
Abstract
Background: Phytosterols are bioactive lipids susceptible to oxidation, particularly under thermal stress. Incorporation into liposomes may enhance their stability, while resveratrol—a natural antioxidant—could further limit thermal degradation. Stigmasterol esters, which contain fatty acid residues prone to oxidation, require additional characterization to understand their [...] Read more.
Background: Phytosterols are bioactive lipids susceptible to oxidation, particularly under thermal stress. Incorporation into liposomes may enhance their stability, while resveratrol—a natural antioxidant—could further limit thermal degradation. Stigmasterol esters, which contain fatty acid residues prone to oxidation, require additional characterization to understand their behavior under heating. Methods: Liposomes composed of dipalmitoylphosphatidylcholine (DPPC) were enriched with free stigmasterol (ST), stigmasteryl myristate (ME), or stigmasteryl oleate (OE), with or without resveratrol (RES). Liposomal systems were characterized using transmission electron microscopy, zeta potential, and hydrodynamic diameter analyses. Samples were heated at 60 °C and 180 °C for 8 h to evaluate stigmasterol degradation, oxyphytosterol (SOP) formation, and decomposition of fatty acid residues in the esters. Results: Liposomes remained structurally stable at 60 °C but underwent marked alterations at 180 °C. ST formed the smallest particles, while ME and OE systems exhibited larger hydrodynamic diameters. Incorporation of resveratrol enhanced thermal and oxidative stability, reducing stigmasterol degradation (7.73–18.86% at 60 °C; 29.66–35.28% at 180 °C) and limiting SOP formation. Differences in the breakdown of myristic versus oleic acid residues highlighted the role of fatty acid type in determining thermal resistance. Conclusions: Resveratrol effectively improves the stability of liposomes containing stigmasterol or its esters and mitigates oxidative damage under thermal stress. Protective effects were particularly evident at moderate temperatures, indicating the potential of resveratrol–phytosterol liposomes as thermally stable delivery systems. Full article
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