Advances in Smart Digital Tools for Research and Development
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Microbial Biotechnology".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 3786
Special Issue Editors
Interests: multivariate analysis; digitalization and modeling of industrial biotechnological and chemical processes; biosimilar monoclonal antibody;
Interests: pattern recognition; wastewater treatment; biotechnology; chemical processes; water treatment; instrumentation; chemical engineering; environmental biotechnology; process development; bioprocess engineering and fermentation technology; industrial biotechnology; nitrogen; bioprocess technology; Escherichia coli; denitrification; nitrification; cell culture techniques; bioenergy; design of experiments; bioreactors; bioprocess development; industrial microbiology; enzyme immobilization; ammonia; nitrite; cell polarity; bioprocess
Special Issue Information
Dear Colleagues,
The landscape of R&D in biotechnology is rapidly changing. Innovations are supported not only by advanced technologies to access versatile information of living systems but also by increasingly automated and parallelized operations in robots as well as by more efficient and self-learning computational approaches. A major pillar unifying these trends is the potential for rapidly generated large datasets with the associated challenge to store, standardize, and process such data. From gene sequencing, through drug screening, to simulation of the dynamic behavior of industrial bioreactors, new methods and tools are being developed, enabling improved understanding, confidence, and decision support. This Special Issue is devoted to the impact of computer-aided methods on the diverse stages of development and manufacture of biopharmaceutical drugs. The focus is set on computer methods that support the different stages and scales in R&D: bioinformatics (gene-level modeling), molecular dynamics simulation, cell-level modeling including MFA and FBA, reactor-scale modeling such as CFD and model-based process control, system-level modeling for high-throughput and sequential experimental design and operation, as well as modeling approaches supporting the regulatory PAT (e.g., soft sensors) and QbD approaches (e.g., process design and optimization).
Possible topics of interest of this Special Issue include, but are not limited to:
- Big Data in gene sequencing
- Genome, metabolic, and flux modeling
- Big Data in bio-analytics and soft sensors
- Big Data in high-throughput systems
- Dynamical modeling of biosystems
- Computational fluid dynamics for bioreactors
- Bioprocess design, optimization, and upscaling
Dr. Michael Sokolov
Dr. Mariano Nicolas Cruz Bournazou
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- big data
- data analytics
- gene sequencing
- omics
- flux balances analysis
- bioprocess modeling
- design of experiments
- multivariate data analysis
- hybrid modeling
- computer aided bioprocess engineering
- bioprocess optimization
- bioprocess automation
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