Redox Modulating Compounds as Potential Antiviral Agents against Viruses

Dear Colleagues,

An imbalance in the redox state towards oxidative stress is a well-known phenomenon that also characterizes viral infections, including those from respiratory viruses, such as Influenza virus and SARS-CoV-2, and neurotropic viruses. Intracellular alteration to oxidant conditions favors viral replication and contributes to virus-induced pathogenesis. Antiviral drugs currently available are limited in number and efficacy by side effects and the development of resistance. Several natural compounds, as well as synthetic derivatives, have been shown to possess antioxidant and/or antiviral properties. In this context, the hypothesis that redox-modulating agents may represent useful complementary tools to control viral infections is of great interest.

We invite colleagues to submit research articles providing data to evaluate this hypothesis.

Review articles about the current state-of-the-art findings are welcome as well.

Potential topics include but are not limited to the following:

• Role of oxidative stress in virus life-cycle
• Characterization of potential antiviral redox-sensitive targets
• Implications of oxidative stress in the host response to viruses
• Antiviral and antioxidant effects of natural and synthetic compounds
• Effects of natural and synthetic compounds on the immune response to viruses

Dr. Maria Elena Marcocci

Dr. Giovanna De Chiara

Dr. Paola Checconi
Guest Editors

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