Fungal Nutrition Assimilation Strategies and Pathogenicity

Dear Colleagues,

Invasive fungal infections are a major cause of morbidity and mortality globally, particularly in patients immunocompromised as a result of HIV infection or the administration of immunosuppressive medications to prevent solid organ, hematopoietic stem cell, or bone marrow transplant rejection. They are also a major cause of disease in plants and therefore threaten the stability of global crop production. The ability of fungi to obtain enough nutrients to support their growth within their host environments is a fundamental requirement for disease outcome. With only a limited repertoire of antifungal agents available, some of which are toxic, lack pan-fungal activity and/or are costly, and the emergence of drug resistance, fungal nutrient acquisition and biosynthetic pathways may therefore provide an alternative avenue to target for future drug development.

This Special Issue focuses on research, which advances our knowledge on how fungi synthesize or acquire sufficient nutrients for proliferation, virulence factor production and the establishment of infection. This research has largely been facilitated by technological advancement in targeted disruption within fungal genomes and the establishment of animal and cell models of fungal infection.

Dr. Julianne Djordjevic
Guest Editor

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