Special Issue "Microbial Biofilms: From Molecular Mechanisms and Structure to Antimicrobial Therapy"

A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Biofilm".

Deadline for manuscript submissions: 31 January 2022.

Special Issue Editors

Prof. Dr. Paolo Landini
E-Mail Website
Guest Editor
Department of Biosciences, University of Milan, 20133 Milan, Italy
Interests: microbial adhesion; gene expression; transcription regulation; antimetabolite drugs; host–pathogen interaction
Dr. Jaione Valle
E-Mail Website
Guest Editor
CSIC-GN- Instituto de Agrobiotecnologia (IDAB), 31192 Pamplona, Spain
Interests: molecular interactions; surface proteins; extracellular matrix; antibiotic resistance; amyloids

Special Issue Information

Dear Colleagues,

The study of microbial biofilms represents a thriving field in every aspect of microbiology, as biofilms play a pivotal role in medical microbiology, environmental microbiology, and microbial biotechnology alike. The investigation of the basic molecular mechanisms leading to biofilm formation, maintenance, and break-up, in different microorganisms, has led to the discovery of some of the most sophisticated signaling and regulatory pathways known to exist in the microbial world.

What we find really fascinating about microbial biofilms is how complex their impact is on human life and activities, and how multifaceted their nature can be in different contexts. To offer a health-related example, it has been estimated that 65% of overall bacterial infections are caused by, or associated with, biofilms, yet a switch from single cell to biofilm is often linked to an overall reduction in production of virulence factors in pathogenic bacteria, and it sometimes constitutes the transition from an acute to a chronic infection. Bacteria in biofilms do not respond to antibiotic therapy as planktonic organisms of the same species do, by activating tolerance mechanisms to antibiotics that differ from bacterial resistance via mutations. These observations eventually led to the definition of bacterial persistence, which in turn introduced the concept of epigenetic mechanisms to the bacterial world and has highlighted how the killing effect of antimicrobial agents is often mediated by mechanisms more complex than simple target inhibition.

In this Special Issue of Microorganisms, we invite scientists with an interest in microbial (i.e., both bacterial and fungal) biofilms to send contributions concerning any aspect related to this field: from the role of mixed biofilms in different ecological niches, including industrial settings and complex microbial communities associated with the human body, to development of novel antimicrobial agents with antibiofilm activity, to investigations on microbial virulence linked to biofilm formation, to the basic regulatory mechanisms presiding over the various steps of the biofilm/planktonic cells cycle, to investigations on the impact of microbial biofilms on human health.

Prof. Dr. Paolo Landini
Dr. Jaione Valle
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microorganisms is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • microbial biofilms
  • microbial communities
  • antimicrobial agents
  • virulence
  • adhesion factors
  • host–pathogen interaction
  • bacterial persistence

Published Papers

This special issue is now open for submission.
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