Special Issue "Updates on Brucellosis"
Deadline for manuscript submissions: closed (31 July 2020).
More than 130 years after the identification of the agent of Malta fever by David Bruce, brucellosis remains an important zoonotic infection causing huge reproductive failure in animal husbandry, and economic losses of the dairy industry in developing countries. The disease is also a serious public health problem for human populations living in endemic areas, because of the consumption of contaminated food and/or occupational exposure to infected livestock. It is estimated that over one-fifth of the 1.4 billion worldwide cattle population are currently infected by Brucella, and the disease affects at least half-a-million new human cases worldwide annually, representing the most common systemic bacterial zoonosis.
Many biological features make members of the genus Brucella formidable foes, such as an extremely low infecting dose; multiple routes of transmission and portals of entry including the gastrointestinal, respiratory, conjunctival, and genital tracts; and despite vaccination programs, surveillance, and test-and-slaughter measures, the disease has proven to be difficult to eradicate.
Intensive research conducted in recent years has made exciting contributions to our understanding of the biology of these intriguing pathogens; discovered new Brucella species outside the traditional ruminant and canid hosts; elucidated the epidemiological importance of the wildlife reservoir of the disease; revealed the complex interaction between phagocyted Brucella and the macrophage cells; and introduced exquisitely sensitive nucleic acid amplification tests to detect the organism in animals, humans, and animal products.
The aim of this Special Issue of Microorganisms is to summarize, among other topics, some of the latest advances in the speciation and genomics of the novel Brucella species; the epidemiology of animal and human brucellosis; the traditional culture and serodiagnostic tools; and as the novel molecular methods, laboratory-acquired infections, and clinical manifestations of the disease in humans, and its antibiotic treatment. Original research contributions and reviews articles are invited.
Prof. Dr. Pablo V. Yagupsky
Manuscript Submission Information
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- human and animal