Resistance of Gram-Negative Bacteria to Last-Resort Antibacterials
A special issue of Microorganisms (ISSN 2076-2607). This special issue belongs to the section "Antimicrobial Agents and Resistance".
Deadline for manuscript submissions: 30 June 2025 | Viewed by 302
Special Issue Editor
Interests: resistance mechanisms of gram-negatives; carbapenemase detection; carbapenem resistance; carbapenemase-producing organisms; resistance genomics; in vitro pk/pd
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Infections due to multi-drug-resistant (MDR), extensively drug-resistant (XDR) and pan-drug-resistant (PDR) Gram-negatives are increasing worldwide, forcing clinicians to use last-resort antimicrobials for their management. These salvage treatment options include the few new antibacterials developed recently (cefiderocol, ceftolozane-tazobactam meropenem-vaborbactam, imipenem-relebactam, ceftazidime- and aztreonam-avibactam, cefepime-taniborbactam, eravacycline and omadacycline) and older antibacterials, like polymyxins and tigecycline. Unfortunately, resistance to last-resort agents is also reported, putting in danger their use and making infections due to these pathogens practically untreatable.
The scope of this Special Issue is to update knowledge on resistance of Gram-negative pathogens to last-resort antimicrobials through manuscripts highlighting their epidemiology, resistance mechanisms and genomics, but also manuscripts addressing alternative treatment options or reversal of resistance methods, like combination therapy, phage therapy, antimicrobial peptides, CRISPR-cas system and PK/PD studies. Finally, manuscripts describing new microbiological tools for resistance detection are also welcome.
Dr. Sophia Vourli
Guest Editor
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Keywords
- last-resort antimicrobials
- mechanisms of resistance to new antimicrobials
- PK/PD of new and old antimicrobials
- combination therapy
- resistance genomics
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