Cefiderocol: An Overview of Antibacterial Activity and Resistance Mechanisms
A Special Issue of Microorganisms (ISSN 2076-2607) belonging to the section "Antimicrobial Agents and Resistance".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 284
Editor
Interests: beta-lactamases; carbapenemases; extended-spectrum beta-lactamases; Acinetobacter baumannii; Enterobacteriaceae
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The rapid spread of carbapenem-resistant Enterobacterales (CRE), carbapenem-resistant Pseudomonas aeruginosa (CRPA) and carbapenem-resistant Acinetobacter baumannii (CRAB) has prompted researchers to develop new drugs such as cefiderocol (FDC), ceftazidime-avibactam, imipenem-relebactam and meropenem-varbobactam, which exhibit activity against carbapenem-resistant Gram-negative bacteria. FDC is a novel siderophore cephalosporin, used to treat septicemia, nosocomial pneumonia and complicated urinary-tract infections, which uses the ferric ion transport system enabling active uptake, bypassing the outer membrane of Gram-negative bacteria. In contrast to β-lactam-inhibitor combinations, FDC demonstrates increased activity against Gram-negative bacteria with all carbapenemase types, including metallo-β-lactamases. It exerts activity against 90% Enterobacterales, P. aeruginosa and A. baumannii. However, resistance emerged recently, among Enterobacterales positive for NDM and OXA-48 and CRAB. The combination of FDC with other antibiotics such as amikacin or colistin was shown to improve its activity and prevent the development of heteroresistance.
The aim of this Special Issue is to collect information about its antibacterial activity, stability to β-lactamases, including carbapenemases, therapeutic effectiveness and molecular epidemiology of resistant isolates.
We welcome manuscript submissions related to the following topics for the Special Issue:
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Antibacterial activity of cefiderocol;
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Resistance mechanisms and resistance trends;
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Molecular epidemiology of cefiderocol resistance;
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Laboratory analysis of antibacterial activity and resistance traits;
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Clinical trials.
Types of articles: research articles, reviews.
Prof. Dr. Branka Bedenic
Guest Editor
Manuscript Submission Information
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Keywords
- cefiderocol
- carbapenemases
- gram-negative bacteria
- NDM
- OXA-48
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